Iron-facilitated oxidative dehydrogenative C-O bond formation by propargylic Csp3-H functionalization

Teng Wang, Wang Zhou, Hang Yin, Jun An Ma, Ning Jiao

Research output: Contribution to journalArticle

42 Scopus citations


Hot couple: Propargyl azides were coupled with carboxylic acids by an iron-catalyzed dehydrogenative C-O bond formation (see scheme). This method enables propargylic C sp 3-H functionalization under mild reaction conditions and also may involve the application of the azido moiety as an assisting group in C-H activation.

Original languageEnglish (US)
Pages (from-to)10823-10826
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number43
StatePublished - Oct 22 2012


  • C-H activation
  • C-O coupling
  • carboxylic acids
  • cations
  • iron

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