Iron-facilitated oxidative dehydrogenative C-O bond formation by propargylic Csp3-H functionalization

Teng Wang; Wang Zhou; Hang Yin; Jun An Ma; Ning Jiao

doi:10.1002/anie.201205779

Iron-facilitated oxidative dehydrogenative C-O bond formation by propargylic C_sp3-H functionalization

Teng Wang, Wang Zhou, Hang Yin, Jun An Ma, Ning Jiao

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Hot couple: Propargyl azides were coupled with carboxylic acids by an iron-catalyzed dehydrogenative C-O bond formation (see scheme). This method enables propargylic C sp 3-H functionalization under mild reaction conditions and also may involve the application of the azido moiety as an assisting group in C-H activation.

Original language	English (US)
Pages (from-to)	10823-10826
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	43
DOIs	https://doi.org/10.1002/anie.201205779
State	Published - Oct 22 2012
Externally published	Yes

Keywords

C-H activation
C-O coupling
carboxylic acids
cations
iron

Publisher link

10.1002/anie.201205779

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abstract = "Hot couple: Propargyl azides were coupled with carboxylic acids by an iron-catalyzed dehydrogenative C-O bond formation (see scheme). This method enables propargylic C sp 3-H functionalization under mild reaction conditions and also may involve the application of the azido moiety as an assisting group in C-H activation.",

keywords = "C-H activation, C-O coupling, carboxylic acids, cations, iron",

author = "Teng Wang and Wang Zhou and Hang Yin and Ma, {Jun An} and Ning Jiao",

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T1 - Iron-facilitated oxidative dehydrogenative C-O bond formation by propargylic Csp3-H functionalization

AU - Wang, Teng

AU - Zhou, Wang

AU - Yin, Hang

AU - Ma, Jun An

AU - Jiao, Ning

PY - 2012/10/22

Y1 - 2012/10/22

N2 - Hot couple: Propargyl azides were coupled with carboxylic acids by an iron-catalyzed dehydrogenative C-O bond formation (see scheme). This method enables propargylic C sp 3-H functionalization under mild reaction conditions and also may involve the application of the azido moiety as an assisting group in C-H activation.

AB - Hot couple: Propargyl azides were coupled with carboxylic acids by an iron-catalyzed dehydrogenative C-O bond formation (see scheme). This method enables propargylic C sp 3-H functionalization under mild reaction conditions and also may involve the application of the azido moiety as an assisting group in C-H activation.

KW - C-H activation

KW - C-O coupling

KW - carboxylic acids

KW - cations

KW - iron

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