Iron-facilitated direct oxidative C-H transformation of allyl arenes to alkenyl aldehydes

Teng Wang; Shi Kai Xiang; Chong Qin; Jun An Ma; Li He Zhang; Ning Jiao

doi:10.1016/j.tetlet.2011.04.041

Iron-facilitated direct oxidative C-H transformation of allyl arenes to alkenyl aldehydes

Teng Wang, Shi Kai Xiang, Chong Qin, Jun An Ma, Li He Zhang, Ning Jiao

Institute for Therapeutics Discovery and Development

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A direct oxidative approach to alkenyl aldehydes from allyl arenes via allyl sp³ C-H functionalization was disclosed. An inexpensive iron catalyst was employed to facilitate this transformation. The mechanistic studies indicate that the cleavage of the allyl sp³ C-H bond is involved in the rate-determining step.

Original language	English (US)
Pages (from-to)	3208-3211
Number of pages	4
Journal	Tetrahedron Letters
Volume	52
Issue number	25
DOIs	https://doi.org/10.1016/j.tetlet.2011.04.041
State	Published - Jun 22 2011

Bibliographical note

Funding Information:
Financial support from Peking University, National Science Foundation of China (Nos. 20702002, 20872003 ) and National Basic Research Program of China (973 Program 2009CB825300) is greatly appreciated.

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10.1016/j.tetlet.2011.04.041

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title = "Iron-facilitated direct oxidative C-H transformation of allyl arenes to alkenyl aldehydes",

abstract = "A direct oxidative approach to alkenyl aldehydes from allyl arenes via allyl sp3 C-H functionalization was disclosed. An inexpensive iron catalyst was employed to facilitate this transformation. The mechanistic studies indicate that the cleavage of the allyl sp3 C-H bond is involved in the rate-determining step.",

author = "Teng Wang and Xiang, {Shi Kai} and Chong Qin and Ma, {Jun An} and Zhang, {Li He} and Ning Jiao",

note = "Funding Information: Financial support from Peking University, National Science Foundation of China (Nos. 20702002, 20872003 ) and National Basic Research Program of China (973 Program 2009CB825300) is greatly appreciated. ",

year = "2011",

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doi = "10.1016/j.tetlet.2011.04.041",

language = "English (US)",

volume = "52",

pages = "3208--3211",

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TY - JOUR

T1 - Iron-facilitated direct oxidative C-H transformation of allyl arenes to alkenyl aldehydes

AU - Wang, Teng

AU - Xiang, Shi Kai

AU - Qin, Chong

AU - Ma, Jun An

AU - Zhang, Li He

AU - Jiao, Ning

N1 - Funding Information: Financial support from Peking University, National Science Foundation of China (Nos. 20702002, 20872003 ) and National Basic Research Program of China (973 Program 2009CB825300) is greatly appreciated.

PY - 2011/6/22

Y1 - 2011/6/22

N2 - A direct oxidative approach to alkenyl aldehydes from allyl arenes via allyl sp3 C-H functionalization was disclosed. An inexpensive iron catalyst was employed to facilitate this transformation. The mechanistic studies indicate that the cleavage of the allyl sp3 C-H bond is involved in the rate-determining step.

AB - A direct oxidative approach to alkenyl aldehydes from allyl arenes via allyl sp3 C-H functionalization was disclosed. An inexpensive iron catalyst was employed to facilitate this transformation. The mechanistic studies indicate that the cleavage of the allyl sp3 C-H bond is involved in the rate-determining step.

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U2 - 10.1016/j.tetlet.2011.04.041

DO - 10.1016/j.tetlet.2011.04.041

M3 - Article

AN - SCOPUS:79956223488

VL - 52

SP - 3208

EP - 3211

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 25

ER -

Iron-facilitated direct oxidative C-H transformation of allyl arenes to alkenyl aldehydes

Abstract

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