Iron Deficiency and Brain Development

Betsy Lozoff, Michael K. Georgieff

Research output: Contribution to journalReview articlepeer-review

392 Scopus citations

Abstract

Iron deficiency (ID) is common in pregnant women and infants worldwide. Rodent models show that ID during gestation/lactation alters neurometabolism, neurotransmitters, myelination, and gene/protein profiles before and after iron repletion at weaning. Human infants with iron deficiency anemia test lower in cognitive, motor, social-emotional, and neurophysiologic development than comparison group infants. Iron therapy does not consistently improve developmental outcome, with long-term differences observed. Poorer outcome has also been shown in human and monkey infants with fetal/neonatal ID. Recent randomized trials of infant iron supplementation show benefits, indicating that adverse effects can be prevented and/or reversed with iron earlier in development or before ID becomes severe or chronic. This body of research emphasizes the importance of protecting the developing brain from ID.

Original languageEnglish (US)
Pages (from-to)158-165
Number of pages8
JournalSeminars in Pediatric Neurology
Volume13
Issue number3
DOIs
StatePublished - Sep 2006

Bibliographical note

Funding Information:
Supported in part by grants from NICHD (P01 HD39386, Brain and Behavior in Early Iron Deficiency, Betsy Lozoff, Principal Investigator, and R01 HD29421, Newborn Iron Deficiency, Michael Georgieff, Principal Investigator).

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

  • anemia
  • basal ganglia
  • brain development
  • hippocampus
  • infant
  • iron deficiency
  • myelination

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