IRF4 translocation status in pediatric follicular and diffuse large B-cell lymphoma patients enrolled in Children's Oncology Group trials

Karen M. Chisholm, Jeffrey Mohlman, Michael Liew, Amanda Termuhlen, Mitchell S. Cairo, Thomas G. Gross, Sherrie L. Perkins, Rodney R. Miles

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Large B-cell lymphoma with IRF4 rearrangement is a provisional entity in the 2017 World Health Organization classification. In order to characterize these lymphomas in children from the United States, IRF4 FISH and immunohistochemical stains were performed on 32 follicular lymphoma and diffuse large B-cell lymphoma (DLBCL) from Children's Oncology Group studies. Two DLBCLs (6%) had IRF4 rearrangements, one involving the ileocecal valve and another involving the tonsil and cerebrospinal fluid. Both cases had strong, diffuse IRF4/MUM1 immunohistochemical staining, which may be a pathologic clue to the diagnosis. Reclassification of these cases may have prognostic and therapeutic implications.

Original languageEnglish (US)
Article numbere27770
JournalPediatric Blood and Cancer
Volume66
Issue number8
DOIs
StatePublished - Aug 2019

Keywords

  • diffuse large B-cell lymphoma
  • follicular lymphoma, IRF4
  • lymphoma
  • pediatric

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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