Ionized form of acetaminophen with improved compaction properties

Sathyanarayana Reddy Perumalla; Limin Shi; Changquan Calvin Sun

doi:10.1039/c1ce06278f

Ionized form of acetaminophen with improved compaction properties

Sathyanarayana Reddy Perumalla
, Limin Shi
, Changquan Calvin Sun

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

The most widely used antipyretic and analgesic drug, acetaminophen, has the long standing problem of extremely poor tableting properties and has been considered as non-ionizable. Here we report the synthesis of the first ionized solid-state structure, acetaminophen HCl monohydrate, and demonstrate its excellent tableting properties.

Original language	English (US)
Pages (from-to)	2389-2390
Number of pages	2
Journal	CrystEngComm
Volume	14
Issue number	7
DOIs	https://doi.org/10.1039/c1ce06278f
State	Published - Apr 7 2012

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10.1039/c1ce06278f

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abstract = "The most widely used antipyretic and analgesic drug, acetaminophen, has the long standing problem of extremely poor tableting properties and has been considered as non-ionizable. Here we report the synthesis of the first ionized solid-state structure, acetaminophen HCl monohydrate, and demonstrate its excellent tableting properties.",

author = "Perumalla, \{Sathyanarayana Reddy\} and Limin Shi and Sun, \{Changquan Calvin\}",

year = "2012",

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AU - Perumalla, Sathyanarayana Reddy

AU - Shi, Limin

AU - Sun, Changquan Calvin

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N2 - The most widely used antipyretic and analgesic drug, acetaminophen, has the long standing problem of extremely poor tableting properties and has been considered as non-ionizable. Here we report the synthesis of the first ionized solid-state structure, acetaminophen HCl monohydrate, and demonstrate its excellent tableting properties.

AB - The most widely used antipyretic and analgesic drug, acetaminophen, has the long standing problem of extremely poor tableting properties and has been considered as non-ionizable. Here we report the synthesis of the first ionized solid-state structure, acetaminophen HCl monohydrate, and demonstrate its excellent tableting properties.

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UR - https://www.scopus.com/pages/publications/84858015910#tab=citedBy

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DO - 10.1039/c1ce06278f

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JO - CrystEngComm

JF - CrystEngComm

IS - 7

ER -

Ionized form of acetaminophen with improved compaction properties

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