Ionized form of acetaminophen with improved compaction properties

Sathyanarayana Reddy Perumalla, Limin Shi, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


The most widely used antipyretic and analgesic drug, acetaminophen, has the long standing problem of extremely poor tableting properties and has been considered as non-ionizable. Here we report the synthesis of the first ionized solid-state structure, acetaminophen HCl monohydrate, and demonstrate its excellent tableting properties.

Original languageEnglish (US)
Pages (from-to)2389-2390
Number of pages2
Issue number7
StatePublished - Apr 7 2012


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