Ion Mobility Mass Spectrometry as an Efficient Tool for Identification of Streptorubin B in Streptomyces coelicolor M145

Andrew P. Marshall, Andrew R. Johnson, Marvin M. Vega, Regan J. Thomson, Erin E. Carlson

Research output: Contribution to journalArticle


Ion mobility spectrometry was utilized to corroborate the identity of streptorubin B (2) as the natural product produced by Streptomyces coelicolor. Natural product 2 was initially assigned as butylcycloheptylprodigiosin (3), and only relatively recently was this assignment clarified. We present additional evidence of this assignment by comparing collisional cross sections (ω) of synthetic standards of 2, 3, and metacycloprodigiosin (4) to the cyclic prodiginine produced by S. coelicolor. Calculated theoretical ω values demonstrate that cyclic prodiginines could be identified without standards. This work highlights ion mobility as an efficient tool for the dereplication of natural products.

Original languageEnglish (US)
Pages (from-to)159-163
Number of pages5
JournalJournal of Natural Products
Issue number1
StatePublished - Jan 24 2020


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  • Journal Article

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