TY - JOUR
T1 - Iodo-Cycloisomerization of Aryl(indol-3-yl)methane-Tethered Propargyl Alcohols to 3-Iodocarbazoles via Selective 1,2-Alkyl Migration
AU - Yaragorla, Srinivasarao
AU - Bag, Debojyoti
AU - Dada, Ravikrishna
AU - Jose, K. V.Jovan
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/11/7
Y1 - 2018/11/7
N2 - Herein, we disclose the first report on iodo-cycloisomerization of 1-(indol-3-yl)-1-arylbut-3-yn-2-ols to form 3-iodocarbazoles. The synthesis proceeds through a cascade 5-endo-spirocyclization, followed by selective 1,2-alkyl migration. This method governs the green synthesis principles such as open-flask reaction, AcOEt as the solvent, rt reaction with short time, use of iodine, and broad substrate scope with atom and step economy.
AB - Herein, we disclose the first report on iodo-cycloisomerization of 1-(indol-3-yl)-1-arylbut-3-yn-2-ols to form 3-iodocarbazoles. The synthesis proceeds through a cascade 5-endo-spirocyclization, followed by selective 1,2-alkyl migration. This method governs the green synthesis principles such as open-flask reaction, AcOEt as the solvent, rt reaction with short time, use of iodine, and broad substrate scope with atom and step economy.
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U2 - 10.1021/acsomega.8b02393
DO - 10.1021/acsomega.8b02393
M3 - Article
AN - SCOPUS:85056464457
SN - 2470-1343
VL - 3
SP - 15024
EP - 15034
JO - ACS Omega
JF - ACS Omega
IS - 11
ER -