Involvement of superoxide in the reactions of the catechol dioxygenases

Ruth Mayer, Joanne Widom, Lawrence Que

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The effect of copper salicylate on the rates of reaction of protocatechuate 3,4-dioxygenase (intradiol cleavage) and 3,4-dihydroxyphenylacetate 2,3-dioxygenase (extradiol cleavage) was monitored. The data obtained is consistent with the dismutation of superoxide by the copper complex resulting in the uncoupling of the oxygen reduction step from the product formation step. Mechanistic interpretations are presented.

Original languageEnglish (US)
Pages (from-to)285-291
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Jan 15 1980


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