Involvement of superoxide in the reactions of the catechol dioxygenases

Ruth Mayer, Joanne Widom, Lawrence Que

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The effect of copper salicylate on the rates of reaction of protocatechuate 3,4-dioxygenase (intradiol cleavage) and 3,4-dihydroxyphenylacetate 2,3-dioxygenase (extradiol cleavage) was monitored. The data obtained is consistent with the dismutation of superoxide by the copper complex resulting in the uncoupling of the oxygen reduction step from the product formation step. Mechanistic interpretations are presented.

Original languageEnglish (US)
Pages (from-to)285-291
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume92
Issue number1
DOIs
StatePublished - Jan 15 1980

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Fingerprint Dive into the research topics of 'Involvement of superoxide in the reactions of the catechol dioxygenases'. Together they form a unique fingerprint.

Cite this