Involvement of serotonin in prolactin release induced by electrical stimulation of the hypothalamus of the Turkey (Meleagris gallopavo)

M E Elhalawani; O. M. Youngren; J. L. Silsby; R. E. Phillips

doi:10.1016/0016-6480(88)90215-8

Involvement of serotonin in prolactin release induced by electrical stimulation of the hypothalamus of the Turkey (Meleagris gallopavo)

M E Elhalawani, O. M. Youngren, J. L. Silsby, R. E. Phillips

Animal Science

Research output: Contribution to journal › Article › peer-review

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Abstract

In anesthetized female turkeys electrical stimulation of the ventromedial nucleus (VMN) for 30 min caused increases in plasma prolactin (Prl); with maximum increase above the prestimulation level being 33.6 ± 5.7 ng/ml for laying hens and 768.1 ± 187.6 ng/ml for incubating hens. The possibility that serotonin (5-HT) plays a role in electrical stimulation-induced Prl release was investigated after administration of methysergide, a 5-HT receptor blocker (20 mg/kg), and stimulation in either the VMN or the infundibular nuclear complex-median eminence (INF-ME) region. Electrical stimulation in both the VMN and INF-ME region caused increases (P < 0.05) in plasma Prl. Pretreatment with methysergide prevented the increase in plasma Prl that follows electrical stimulation in the VMN but had no effect on electrical stimulation-induced Prl release in the INF-ME region. We conclude that Prl release in the female turkey requires the functional integrity of serotonergic neurons within, the VMN.

Original language	English (US)
Pages (from-to)	323-328
Number of pages	6
Journal	General and Comparative Endocrinology
Volume	72
Issue number	2
DOIs	https://doi.org/10.1016/0016-6480(88)90215-8
State	Published - Nov 1988

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title = "Involvement of serotonin in prolactin release induced by electrical stimulation of the hypothalamus of the Turkey (Meleagris gallopavo)",

abstract = "In anesthetized female turkeys electrical stimulation of the ventromedial nucleus (VMN) for 30 min caused increases in plasma prolactin (Prl); with maximum increase above the prestimulation level being 33.6 ± 5.7 ng/ml for laying hens and 768.1 ± 187.6 ng/ml for incubating hens. The possibility that serotonin (5-HT) plays a role in electrical stimulation-induced Prl release was investigated after administration of methysergide, a 5-HT receptor blocker (20 mg/kg), and stimulation in either the VMN or the infundibular nuclear complex-median eminence (INF-ME) region. Electrical stimulation in both the VMN and INF-ME region caused increases (P < 0.05) in plasma Prl. Pretreatment with methysergide prevented the increase in plasma Prl that follows electrical stimulation in the VMN but had no effect on electrical stimulation-induced Prl release in the INF-ME region. We conclude that Prl release in the female turkey requires the functional integrity of serotonergic neurons within, the VMN.",

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AU - Elhalawani, M E

AU - Youngren, O. M.

AU - Silsby, J. L.

AU - Phillips, R. E.

PY - 1988/11

Y1 - 1988/11

N2 - In anesthetized female turkeys electrical stimulation of the ventromedial nucleus (VMN) for 30 min caused increases in plasma prolactin (Prl); with maximum increase above the prestimulation level being 33.6 ± 5.7 ng/ml for laying hens and 768.1 ± 187.6 ng/ml for incubating hens. The possibility that serotonin (5-HT) plays a role in electrical stimulation-induced Prl release was investigated after administration of methysergide, a 5-HT receptor blocker (20 mg/kg), and stimulation in either the VMN or the infundibular nuclear complex-median eminence (INF-ME) region. Electrical stimulation in both the VMN and INF-ME region caused increases (P < 0.05) in plasma Prl. Pretreatment with methysergide prevented the increase in plasma Prl that follows electrical stimulation in the VMN but had no effect on electrical stimulation-induced Prl release in the INF-ME region. We conclude that Prl release in the female turkey requires the functional integrity of serotonergic neurons within, the VMN.

AB - In anesthetized female turkeys electrical stimulation of the ventromedial nucleus (VMN) for 30 min caused increases in plasma prolactin (Prl); with maximum increase above the prestimulation level being 33.6 ± 5.7 ng/ml for laying hens and 768.1 ± 187.6 ng/ml for incubating hens. The possibility that serotonin (5-HT) plays a role in electrical stimulation-induced Prl release was investigated after administration of methysergide, a 5-HT receptor blocker (20 mg/kg), and stimulation in either the VMN or the infundibular nuclear complex-median eminence (INF-ME) region. Electrical stimulation in both the VMN and INF-ME region caused increases (P < 0.05) in plasma Prl. Pretreatment with methysergide prevented the increase in plasma Prl that follows electrical stimulation in the VMN but had no effect on electrical stimulation-induced Prl release in the INF-ME region. We conclude that Prl release in the female turkey requires the functional integrity of serotonergic neurons within, the VMN.

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Involvement of serotonin in prolactin release induced by electrical stimulation of the hypothalamus of the Turkey (Meleagris gallopavo)

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