Involvement of opioid receptor subtypes in rat feeding behavior

Donald A. Simone, Richard J. Bodnar, Ellen J. Goldman, Gavril W. Pasternak

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


The short-acting opiate antagonist naloxone decreases food intake in three models of ingestive behavior: free feeding, food-deprivation induced feeding and deoxyglucose-induced feeding. Twenty-four hours after administration, the long-acting, mu1 selective antagonist naloxonazine inhibits food intake to the same extent as naloxone in freely feeding and food-deprived rats, but not in animals treated with 2-deoxyglucose. These results indicate that 1) opiates modulate feeding through multiple opioid receptor mechanisms, one of which is the mu subtype, and 2) the feeding observed in various experimental paradigms are modulated by different receptor subtypes. Furthermore, these results illustrate the usefulness of naloxone in defining a behavior as opioid but point out its limitations in discriminating between opioid receptor subtypes.

Original languageEnglish (US)
Pages (from-to)829-833
Number of pages5
JournalLife Sciences
Issue number9
StatePublished - Mar 4 1985
Externally publishedYes

Bibliographical note

Funding Information:
We thank Drs. Posner, Shapiro and Hahn for their assistance with these studies and Endo Laboratories for their generous gift of naloxone. This work was supported by a PSC/CUNY grant (RIB) and grants from NIDA (DA02615) and the American Cancer Society (PDT169) (GWP).


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