Involvement of noradrenergic system in a remarkably rapid tongue clonus produced by acute hypnotic doses of ethanol in Fischer F344 rats

M. K. Menon, R. L. Lloyd

Research output: Contribution to journalArticlepeer-review

Abstract

Ethanol (2.95 g/kg, IP) eliminated the righting reflex and induced vigorous tongue clonus spontaneously or following tactile tongue stimulation in Fischer F344 rats. Responses normally lasted 30-60 min, and was reinstated by tactile stimulation in those cases where it subsided quickly. Sub-hypnotic (1.95 g/kg) or high (3.95 g/kg) doses failed to elicit clonus, even after tactile stimulation. A lipophilic α1-adrenergic agonist (St 587) promptly initiated tongue clonus in rats treated with a 3.95 g/kg dose of ethanol. Prazosin, a selective α1-adrenergic antagonist, blocked clonus, while the dopamine selective antagonist pimozide failed to modify this response. We infer an α1-adrenergic effect in which norepinephrine is released by ethanol.

Original languageEnglish (US)
Pages (from-to)497-500
Number of pages4
JournalPsychopharmacology
Volume99
Issue number4
DOIs
StatePublished - Dec 1 1989

Keywords

  • Ethanol
  • Ethanol abuse
  • Norepinephrine
  • Tongue dyskinesias
  • α-Adrenergic system

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