Involvement of dynorphin and the kappa opioid receptor in feeding

John E. Morley, Allen S. Levine

Research output: Contribution to journalArticlepeer-review

145 Scopus citations


Dynorphin-(1-17) produces a highly specific increase in food ingestion. Similar enhancement of food ingestion is found with dynorphin fragments (1-10), (1-11), (1-13) and (3-13) but not with (1-8) and (1-9). Dynorphin B (rimorphin) also enhances food intake. The highly specific kappa agonist U-50,488 also enhances food intake as do a number of other kappa-opiate receptor agonists. These studies provided further support for the role of a highly specific dynorphin-kappa opioid receptor in the modulation of feeding.

Original languageEnglish (US)
Pages (from-to)797-800
Number of pages4
Issue number6
StatePublished - 1983

Bibliographical note

Funding Information:
We thank Martha Grace and Julie Kneip for excellent technical assistance. JoAnn Tallman provided secretarial assistance. This work was supported in part by the Veterans Administration.


  • Appetite
  • Dynorphin
  • Feeding
  • Kappa receptor
  • Opioids
  • Rimorphin


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