Involvement of descending facilitation from the rostral ventromedial medulla in the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress

Hiroki Imbe, Keiichiro Okamoto, Tomohiro Donishi, Emiko Senba, Akihisa Kimura

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36 Scopus citations

Abstract

In the present study we examined whether the descending facilitation from the rostral ventromedial medulla (RVM) is required for the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress. Rats were subjected to forced or sham swim stress for 3 days. Withdrawal latency to noxious thermal stimuli and mechanical withdrawal threshold to von Frey filaments did not change significantly in both groups at 24 h after the last stress session. The forced swim stress showed significantly enhanced nocifensive behavior to the subcutaneous administration of formalin at 2 days after the last stress session (1330.1 ± 62.8 s), compared to the sham swim (1076 ± 102.4 s, p < 0.05) and naive groups (825.9 ± 83.2 s, p < 0.01). The destruction of the RVM with ibotenic acid led to prevent the enhancement of formalin-evoked nocifensive behavior in the forced swim group. These findings suggest that the descending facilitation from the RVM may be involved in the enhancement of formalin-evoked nocifensive behavior following the forced swim stress.

Original languageEnglish (US)
Pages (from-to)103-112
Number of pages10
JournalBrain Research
Volume1329
DOIs
StatePublished - May 6 2010

Keywords

  • Descending system
  • Formalin
  • Hyperalgesia
  • Stress

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