Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine

D. S. Ugdyzhekova, Yu G. Davydova, L. A. Maimeskulova, R. Mechoulam

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Intravenous injection of the selective cannabinoid receptor agonist HU-210 in doses of 0.05 and 0.25 mg/kg increased heart resistance to arrhythmogenic effects of epinephrine, while intracerebroventricular infusion of this substance had no effect on the incidence of epinephrine-induced arrhythmia. The selective antagonist of type I cannabinoid receptors SR141716A in a dose of 3 mg/kg and ganglion blocker hexamethonium in a dose of 10 mg/kg did not modify the antiarrhythmic effect of HU-210. This effect of HU-210 is probably related to activation of type II peripheral cannabinoid receptors.

Original languageEnglish (US)
Pages (from-to)1087-1089
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume130
Issue number11
DOIs
StatePublished - Jan 1 2000

Keywords

  • Cannabinoid receptors
  • Epinephrine-induced arrhythmia

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