Invited review: Nutrition and heart failure: Impact of drug therapies and management strategies

Steven P. Dunn, Barry Bleske, Michael Dorsch, Tracy Macaulay, Benjamin Van Tassell, Orly Vardeny

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Nutrition impairment commonly occurs in patients with heart failure and affects disease progression. Vitamin and mineral deficiencies are associated with early mortality, particularly in patients classified as cachectic. Guideline-based therapies approved for heart failure, such as loop diuretics, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, aldosterone antagonists, and Î2-adrenergic blockers, can lead to electrolyte abnormalities and predispose to some vitamin and micronutrient deficits. Clinical trial evidence in support of supplementary vitamin and mineral therapies for heart failure patients is limited with the exception of documented calcium and possibly vitamin D, thiamine, and coenzyme Q10 deficiencies. This area is gaining significant attention, and research is ongoing. The clinician can help minimize morbidity from nutrition impairment through appropriate monitoring and correction of baseline and medication-induced electrolyte imbalances, in addition to vitamin and mineral supplementation when appropriate.

Original languageEnglish (US)
Pages (from-to)60-75
Number of pages16
JournalNutrition in Clinical Practice
Issue number1
StatePublished - Feb 2009


  • Drug therapy
  • Electrolytes
  • Heart failure
  • Nutrition therapy
  • Vitamins


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