Invited review

Lung edema clearance: Role of Na+-K+-ATPase

J. I. Sznajder, P. Factor, David H Ingbar

Research output: Contribution to journalReview article

90 Citations (Scopus)

Abstract

Acute hypoxemic respiratory failure is a consequence of edema accumulation due to elevation of pulmonary capillary pressures and/or increases in permeability of the alveolocapillary barrier. It has been recognized that lung edema clearance is distinct from edema accumulation and is largely effected by active Na+ transport out of the alveoli rather than reversal of the Starling forces, which control liquid flux from the pulmonary circulation into the alveolus. The alveolar epithelial Na+-K+-ATPase has an important role in regulating cell integrity and homeostasis. In the last 15 yr, Na+,K+-ATPase has been localized to the alveolar epithelium and its contribution to lung edema clearance has been appreciated. The importance of the alveolar epithelial Na+-K+-ATPase function is reflected in the changes in the lung's ability to clear edema when the Na+-K+-ATPase is inhibited or increased. An important focus of the ongoing research is the study of the mechanisms of Na+-K+-ATPase regulation in the alveolar epithelium during lung injury and how to accelerate lung edema clearance by modulating Na+-K+-ATPase activity.

Original languageEnglish (US)
Pages (from-to)1860-1866
Number of pages7
JournalJournal of Applied Physiology
Volume93
Issue number5
DOIs
StatePublished - Nov 1 2002

Fingerprint

Edema
Lung
Epithelium
Starlings
Pulmonary Circulation
Active Biological Transport
Lung Injury
Respiratory Insufficiency
sodium-translocating ATPase
Permeability
Homeostasis
Pressure
Research

Keywords

  • Acute respiratory distress syndrome
  • Alveolar epithelium
  • Ion transport

Cite this

Invited review : Lung edema clearance: Role of Na+-K+-ATPase. / Sznajder, J. I.; Factor, P.; Ingbar, David H.

In: Journal of Applied Physiology, Vol. 93, No. 5, 01.11.2002, p. 1860-1866.

Research output: Contribution to journalReview article

Sznajder, J. I. ; Factor, P. ; Ingbar, David H. / Invited review : Lung edema clearance: Role of Na+-K+-ATPase. In: Journal of Applied Physiology. 2002 ; Vol. 93, No. 5. pp. 1860-1866.
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