Investigational procedures in benign prostatic hypertrophy

Joseph Acquaye, Michael S Borofsky

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Purpose of review As benign prostatic hypertrophy (BPH) becomes a more common disease, there has been a dramatic rise in the number of investigational procedures being developed to manage it. We seek to present an overview of the most recently developed treatments and present clinical data related to application wherever available. Recent findings As a greater number of treatments become available for BPH, improved diagnostic testing could prove beneficial in helping guide patient selection. Efforts are underway to identify serum biomarkers associated with BPH as well as new classifications strategies, specifically with MRI, to determine both the anatomy of BPH as well as its histologic distribution. Outpatient-based procedures for BPH currently being developed include the temporary implantable nitinol device as well as intraprostatic injections such as Botox and PRX302. Aquablation is a novel technique that uses robotically guided high-pressured saline to ablate prostate tissue. Early data suggests noninferiority compared with TURP. Finally, efforts are underway to apply robotics to BPH with the advent of a robotic transurethral platform being designed for prostate enucleation. Summary Many new techniques are poised to be introduced to the BPH market over the coming years. The unique risk/benefit profiles as well as associated clinical outcomes of each will need to be studied in detail in order to help identify proper roles in the management of patients with symptomatic disease.

Original languageEnglish (US)
Pages (from-to)315-321
Number of pages7
JournalCurrent Opinion in Urology
Issue number3
StatePublished - May 1 2018

Bibliographical note

Publisher Copyright:
© 2018 Wolters Kluwer Health, Inc. All rights reserved.


  • benign prostatic hypertrophy
  • investigational
  • procedure
  • prostate
  • technology


Dive into the research topics of 'Investigational procedures in benign prostatic hypertrophy'. Together they form a unique fingerprint.

Cite this