A von Willebrand-faktornak, mint az endothelium diszfunkció markerének vizsgálata érbetegekben.

Translated title of the contribution: Investigation of von Willebrand-factor as a marker of endothelial dysfunction in atherosclerotic patients

Beáta Horváth, Dalma Hegedüs, László Szapáry, Zsolt Márton, Tamás Alexy, Katalin Koltai, Zsuzsanna Gyevnár, István Juricskay, Kálmán Tóth, Gábor Késmárky

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

OBJECTIVE: To determine von Willebrand-factor activity as the marker of endothelium dysfunction in vascular diseases and to compare it to healthy controls. METHODS: von Willebrand-factor activity was determined by enzyme-linked immunosorbant assay (ELISA) in patients with acute coronary syndromes (29 patients, 67 +/- 13 years), acute stroke (15 pts, 67 +/- 12 years) on admission, 2nd and 6th day; and chronic vascular diseases (56 pts, 67 +/- 10 years) and was compared to the values of healthy controls (23 persons, 36 +/- 12 years). RESULTS: von Willebrand-factor activity was significantly (p < 0.001) higher in all the measured vascular patients than in the control group. The values of acute patients were significantly (p < 0.05-0.001) higher than those of patients with chronic vascular diseases. In the hospital phase von Willebrand-factor activity in acute patients increased continuously and on day 6 was significantly (p < 0.05-0.01) higher than on admission. von Willebrand-factor activity was significantly (p < 0.05) higher in troponin positive patients with acute coronary syndromes compared to the troponin negative subjects. CONCLUSIONS: von Willebrand-factor was found to be a suitable marker of endothelial dysfunction. The higher von Willebrand-factor activity in patients with vascular diseases compared to the control group can be caused by the endothelial dysfunction and extensive atherosclerosis. The significantly higher von Willebrand-factor activity in acute disorders suggests the more severe endothelium dysfunction and could be related to the development of acute event through increased platelet adhesion and aggregation.

Translated title of the contributionInvestigation of von Willebrand-factor as a marker of endothelial dysfunction in atherosclerotic patients
Original languageHungarian
Pages (from-to)2471-2476
Number of pages6
JournalOrvosi hetilap
Volume144
Issue number50
StatePublished - Dec 14 2003

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