Investigation of SARS-CoV-2 Epsilon Variant and Hospitalization Status by Genomic Surveillance in a Single Large Health System During the 2020-2021 Winter Surge in Southern California

Shangxin Yang; Peera Hemarajata; Evann E. Hilt; Travis K. Price; Omai B. Garner; Nicole M. Green

doi:10.1093/ajcp/aqab203

Investigation of SARS-CoV-2 Epsilon Variant and Hospitalization Status by Genomic Surveillance in a Single Large Health System During the 2020-2021 Winter Surge in Southern California

Shangxin Yang, Peera Hemarajata, Evann E. Hilt, Travis K. Price, Omai B. Garner, Nicole M. Green

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objectives: This study aimed to assess whether the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Epsilon variant (B.1.429/427) is more virulent, leading to more hospitalization and more severe disease requiring intensive care unit (ICU) admission. Methods: SARS-CoV-2 genomic surveillance was performed on respiratory samples from 231 unique patients, collected at a single large health system in Southern California between November 2020 and March 2021 during the winter surge. Results: The frequencies of the Epsilon variant among outpatients, hospitalized patients, and ICU patients were indifferent. Conclusions: Our study suggests that the Epsilon variant is not associated with increased hospitalization and ICU admission.

Original language	English (US)
Pages (from-to)	649-652
Number of pages	4
Journal	American journal of clinical pathology
Volume	157
Issue number	5
DOIs	https://doi.org/10.1093/ajcp/aqab203
State	Published - May 1 2022
Externally published	Yes

Bibliographical note

Funding Information:
This study was mainly funded by the CDC Epidemiology and Laboratory Capacity for Infectious Diseases grant (NU50CK000498) and partially funded by the UCLA Department of Pathology and Laboratory Medicine

Publisher Copyright:
© 2021 American Society for Clinical Pathology, 2021. All rights reserved.

Keywords

B.1.427
B.1.429
COVID-19
California
Epsilon variant
Genomic surveillance
Hospitalization
ICU
SARS-CoV-2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ajcp/aqab203

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Investigation of SARS-CoV-2 Epsilon Variant and Hospitalization Status by Genomic Surveillance in a Single Large Health System During the 2020-2021 Winter Surge in Southern California. / Yang, Shangxin; Hemarajata, Peera; Hilt, Evann E. et al.
In: American journal of clinical pathology, Vol. 157, No. 5, 01.05.2022, p. 649-652.

Research output: Contribution to journal › Article › peer-review

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title = "Investigation of SARS-CoV-2 Epsilon Variant and Hospitalization Status by Genomic Surveillance in a Single Large Health System During the 2020-2021 Winter Surge in Southern California",

abstract = "Objectives: This study aimed to assess whether the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Epsilon variant (B.1.429/427) is more virulent, leading to more hospitalization and more severe disease requiring intensive care unit (ICU) admission. Methods: SARS-CoV-2 genomic surveillance was performed on respiratory samples from 231 unique patients, collected at a single large health system in Southern California between November 2020 and March 2021 during the winter surge. Results: The frequencies of the Epsilon variant among outpatients, hospitalized patients, and ICU patients were indifferent. Conclusions: Our study suggests that the Epsilon variant is not associated with increased hospitalization and ICU admission.",

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author = "Shangxin Yang and Peera Hemarajata and Hilt, {Evann E.} and Price, {Travis K.} and Garner, {Omai B.} and Green, {Nicole M.}",

note = "Funding Information: This study was mainly funded by the CDC Epidemiology and Laboratory Capacity for Infectious Diseases grant (NU50CK000498) and partially funded by the UCLA Department of Pathology and Laboratory Medicine Publisher Copyright: {\textcopyright} 2021 American Society for Clinical Pathology, 2021. All rights reserved.",

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AU - Price, Travis K.

AU - Garner, Omai B.

AU - Green, Nicole M.

N1 - Funding Information: This study was mainly funded by the CDC Epidemiology and Laboratory Capacity for Infectious Diseases grant (NU50CK000498) and partially funded by the UCLA Department of Pathology and Laboratory Medicine Publisher Copyright: © 2021 American Society for Clinical Pathology, 2021. All rights reserved.

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AB - Objectives: This study aimed to assess whether the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Epsilon variant (B.1.429/427) is more virulent, leading to more hospitalization and more severe disease requiring intensive care unit (ICU) admission. Methods: SARS-CoV-2 genomic surveillance was performed on respiratory samples from 231 unique patients, collected at a single large health system in Southern California between November 2020 and March 2021 during the winter surge. Results: The frequencies of the Epsilon variant among outpatients, hospitalized patients, and ICU patients were indifferent. Conclusions: Our study suggests that the Epsilon variant is not associated with increased hospitalization and ICU admission.

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Investigation of SARS-CoV-2 Epsilon Variant and Hospitalization Status by Genomic Surveillance in a Single Large Health System During the 2020-2021 Winter Surge in Southern California

Abstract

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Keywords

UN SDGs

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