Investigation of pH sensitivity of poly(acrylic acid-co-acrylamide) hydrogel

Xianju Zhou, Lihui Weng, Qiang Chen, Jianming Zhang, Deyan Shen, Zhuchuan Li, Manjun Shao, Jian Xu

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43 Scopus citations


It was found that the upper critical solution temperature (UCST) of poly(acrylic acid-co-acrylamide) hydrogel decreases with increase in pH. The UCST of samples equilibrated in a buffer at pH 2.5 was 33.7°C, whereas it shifted to below O°C when swollen in buffers above pH 10. FT-IR showed that COOH group of acrylic acid ionized gradually in alkaline media. The morphology change of the hydrogel swollen in different buffers was studied by environmental scanning electron microscopy (ESEM). ESEM images showed that the pore size of the sample increased with increase in pH, and in strongly basic media the three-dimensional network was replaced by a 'sausage-like' or 'desert-like' structure. A study of the pH-dependent release of cefazolin sodium was also carried out.

Original languageEnglish (US)
Pages (from-to)1153-1157
Number of pages5
JournalPolymer International
Issue number7
StatePublished - Jul 2003


  • Hydrogel
  • PH sensitivity
  • Poly(acrylic acid-co-acrylamide)
  • Upper critical solution temperature


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