Investigation of morphological, mechanical and biological properties of cellulose nanocrystal reinforced electrospun gelatin nanofibers

Ahmad Hivechi; S. Hajir Bahrami; Ronald A Siegel

doi:10.1016/j.ijbiomac.2018.11.214

Investigation of morphological, mechanical and biological properties of cellulose nanocrystal reinforced electrospun gelatin nanofibers

Ahmad Hivechi, S. Hajir Bahrami, Ronald A Siegel

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Incorporation of nanoparticles into biomaterials is of interest due to the high demand for medical devices with enhanced mechanical properties. In this study, cellulose nanocrystals (CNC) were incorporated in electrospun gelatin nanofibers at various loadings (0–15% w/w) and characterized using XRD, TGA, TEM, SEM, FTIR, and tensile tests. Results obtained from TGA and tensile properties indicate that CNC were agglomerated at loadings exceeding 5%; however, TEM showed excellent dispersion of nanoparticles at 5% CNC. A slight increase in biodegradability of crosslinked gelatin nanofibers was observed with CNC incorporation. MTT cytotoxicity, fluorescent staining, and SEM images showed that CNC had no significant effect on cell growth and proliferation.

Original language	English (US)
Pages (from-to)	411-417
Number of pages	7
Journal	International Journal of Biological Macromolecules
Volume	124
DOIs	https://doi.org/10.1016/j.ijbiomac.2018.11.214
State	Published - Mar 1 2019

Bibliographical note

Funding Information:
This work was supported by Iran's National Talents Foundation , Nanotechnology Innovation Council (INIC), and Ministry of Science, Research and Technology . We thank Prof. Raj Suryanarayanan for use of TGA equipment, and Prof. Chun Wang and Mr. Samuel Hanson for help with cell culture experiments. Parts of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF-funded Materials Research Facilities Network ( www.mrfn.org ) via the MRSEC program.

Funding Information:
This work was supported by Iran's National Talents Foundation, Nanotechnology Innovation Council (INIC), and Ministry of Science, Research and Technology. We thank Prof. Raj Suryanarayanan for use of TGA equipment, and Prof. Chun Wang and Mr. Samuel Hanson for help with cell culture experiments. Parts of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF-funded Materials Research Facilities Network (www.mrfn.org) via the MRSEC program.

Publisher Copyright:
© 2018

Keywords

Biological properties
Cellulose nanocrystals
Gelatin nanofibers

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10.1016/j.ijbiomac.2018.11.214

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title = "Investigation of morphological, mechanical and biological properties of cellulose nanocrystal reinforced electrospun gelatin nanofibers",

abstract = "Incorporation of nanoparticles into biomaterials is of interest due to the high demand for medical devices with enhanced mechanical properties. In this study, cellulose nanocrystals (CNC) were incorporated in electrospun gelatin nanofibers at various loadings (0–15% w/w) and characterized using XRD, TGA, TEM, SEM, FTIR, and tensile tests. Results obtained from TGA and tensile properties indicate that CNC were agglomerated at loadings exceeding 5%; however, TEM showed excellent dispersion of nanoparticles at 5% CNC. A slight increase in biodegradability of crosslinked gelatin nanofibers was observed with CNC incorporation. MTT cytotoxicity, fluorescent staining, and SEM images showed that CNC had no significant effect on cell growth and proliferation.",

keywords = "Biological properties, Cellulose nanocrystals, Gelatin nanofibers",

author = "Ahmad Hivechi and {Hajir Bahrami}, S. and Siegel, {Ronald A}",

note = "Funding Information: This work was supported by Iran's National Talents Foundation , Nanotechnology Innovation Council (INIC), and Ministry of Science, Research and Technology . We thank Prof. Raj Suryanarayanan for use of TGA equipment, and Prof. Chun Wang and Mr. Samuel Hanson for help with cell culture experiments. Parts of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF-funded Materials Research Facilities Network ( www.mrfn.org ) via the MRSEC program. Funding Information: This work was supported by Iran's National Talents Foundation, Nanotechnology Innovation Council (INIC), and Ministry of Science, Research and Technology. We thank Prof. Raj Suryanarayanan for use of TGA equipment, and Prof. Chun Wang and Mr. Samuel Hanson for help with cell culture experiments. Parts of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF-funded Materials Research Facilities Network (www.mrfn.org) via the MRSEC program. Publisher Copyright: {\textcopyright} 2018",

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AU - Hivechi, Ahmad

AU - Hajir Bahrami, S.

AU - Siegel, Ronald A

N1 - Funding Information: This work was supported by Iran's National Talents Foundation , Nanotechnology Innovation Council (INIC), and Ministry of Science, Research and Technology . We thank Prof. Raj Suryanarayanan for use of TGA equipment, and Prof. Chun Wang and Mr. Samuel Hanson for help with cell culture experiments. Parts of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF-funded Materials Research Facilities Network ( www.mrfn.org ) via the MRSEC program. Funding Information: This work was supported by Iran's National Talents Foundation, Nanotechnology Innovation Council (INIC), and Ministry of Science, Research and Technology. We thank Prof. Raj Suryanarayanan for use of TGA equipment, and Prof. Chun Wang and Mr. Samuel Hanson for help with cell culture experiments. Parts of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF-funded Materials Research Facilities Network (www.mrfn.org) via the MRSEC program. Publisher Copyright: © 2018

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Incorporation of nanoparticles into biomaterials is of interest due to the high demand for medical devices with enhanced mechanical properties. In this study, cellulose nanocrystals (CNC) were incorporated in electrospun gelatin nanofibers at various loadings (0–15% w/w) and characterized using XRD, TGA, TEM, SEM, FTIR, and tensile tests. Results obtained from TGA and tensile properties indicate that CNC were agglomerated at loadings exceeding 5%; however, TEM showed excellent dispersion of nanoparticles at 5% CNC. A slight increase in biodegradability of crosslinked gelatin nanofibers was observed with CNC incorporation. MTT cytotoxicity, fluorescent staining, and SEM images showed that CNC had no significant effect on cell growth and proliferation.

AB - Incorporation of nanoparticles into biomaterials is of interest due to the high demand for medical devices with enhanced mechanical properties. In this study, cellulose nanocrystals (CNC) were incorporated in electrospun gelatin nanofibers at various loadings (0–15% w/w) and characterized using XRD, TGA, TEM, SEM, FTIR, and tensile tests. Results obtained from TGA and tensile properties indicate that CNC were agglomerated at loadings exceeding 5%; however, TEM showed excellent dispersion of nanoparticles at 5% CNC. A slight increase in biodegradability of crosslinked gelatin nanofibers was observed with CNC incorporation. MTT cytotoxicity, fluorescent staining, and SEM images showed that CNC had no significant effect on cell growth and proliferation.

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KW - Gelatin nanofibers

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Investigation of morphological, mechanical and biological properties of cellulose nanocrystal reinforced electrospun gelatin nanofibers

Abstract

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