Knowledge of the Depth-Of-Interaction (DOI) in detector is crucial for small ring diameter PET scanner but it is also very important for single photon emission imaging, in particular for applications where very high spatial resolution is required and position distortions caused by slant collimators can strongly affect the final response of the 3D reconstructed image. In addition the DOI determination at 140 keV is the most critical due to thinner crystal thickness and the lower number of scintillation light photons. Continuous scintillation crystals are in principle the most suitable for continuous DOI determination based on the measurements of light width of cones generated at each gamma ray interaction. In this work we propose an analysis based on a Monte Carlo GEANT4 studies and on experimental measurements at 140 keV performed on a small LaBr3:Ce continuous crystal coupled to latest multi-anode PMT Hamamatsu H8500-MOD8 series equipped with super Bialkali photocathode (SBA). The basic idea of this work is that the high light output of LaBr3:Ce joint with SBA photodetector can reduces statistical uncertainties related to the light distribution spread determination. Furthermore it can be crucial with a more precise measurement of scintillation light distribution from the 8x8 anode array of MAPMT. Measurements and simulation confirm that light distribution spread (SD) is related to DOI, with a DOI resolution of about 2.0-2.2 mm (Monte Carlo) and 2.8-3.0 mm experimental at 140 keV. In addition, we shown how the selection in SD window provide a 10% of spatial resolution improvement, down to (0.85±0.03) mm, for a LaBr3(Ce) continuous crystal coupled to the new photodetector H8500-MOD8. This method can open the possibility to build a high-sensitivity detector with DOI capability useful for gamma-ray imaging application.