Investigation of Commercial Iron Oxide Nanoparticles: Structural and Magnetic Property Characterization

Kai Wu, Jinming Liu, Renata Saha, Chaoyi Peng, Diqing Su, Yongqiang Andrew Wang, Jian Ping Wang

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Magnetic nanoparticles (MNPs) have been extensively used as tiny heating sources in magnetic hyperthermia therapy, contrast agents in magnetic resonance imaging, tracers in magnetic particle imaging, carriers for drug/gene delivery, etc. There have emerged many MNP/microbead suppliers since the past decade, such as Ocean NanoTech, Nanoprobes, US Research Nanomaterials, Miltenyi Biotec, micromod Partikeltechnologie GmbH, nanoComposix, and so forth. In this paper, we report the physical and magnetic characterizations on iron oxide nanoparticle products from Ocean NanoTech. Standard characterization tools such as vibrating-sample magnetometry, X-ray diffraction, dynamic light scattering, transmission electron microscopy, and zeta potential analysis are used to provide MNP customers and researchers with an overview of these iron oxide nanoparticle products. In addition, the dynamic magnetic responses of these iron oxide nanoparticles in aqueous solutions are investigated under low- and high-frequency alternating magnetic fields, giving a standardized operating procedure for characterizing the MNPs from Ocean NanoTech, thereby yielding the best of MNPs for different applications.

Original languageEnglish (US)
Pages (from-to)6274-6283
Number of pages10
JournalACS Omega
Issue number9
StatePublished - Mar 9 2021

Bibliographical note

Funding Information:
This study was financially supported by the Institute of Engineering in Medicine of the University of Minnesota through the FY18 IEM Seed Grant Funding Program. This study was also financially supported by the U.S. Department of Agriculture—National Institute of Food and Agriculture (NIFA) under Award Number 2020-67021-31956. Portions of this work were conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under Award Number ECCS-1542202. Portions of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF-funded Materials Research Facilities Network ( ) via the MRSEC program.

Publisher Copyright:
© 2021 The Authors. Published by American Chemical Society.


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