TY - JOUR
T1 - Investigating the effect of magnetic dipole-dipole interaction on magnetic particle spectroscopy
T2 - Implications for magnetic nanoparticle-based bioassays and magnetic particle imaging
AU - Wu, Kai
AU - Su, Diqing
AU - Saha, Renata
AU - Liu, Jinming
AU - Wang, Jian Ping
N1 - Publisher Copyright:
© 2019 IOP Publishing Ltd.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/6/17
Y1 - 2019/6/17
N2 - Superparamagnetic iron oxide nanoparticles (SPIONs), with comparable size to biomolecules (such as proteins, nucleic acids, etc) and unique magnetic properties, good biocompatibility, low toxicity, potent catalytic behavior, are promising candidates for many biomedical applications. There is one property present in most SPION systems, yet it has not been fully exploited, which is the dipole-dipole interaction (also called dipolar interaction) between the SPIONs. It is known that the magnetic dynamics of an ensemble of SPIONs are substantially influenced by the dipolar interactions. However, the exact way it affects the performance of magnetic particle-based bioassays and magnetic particle imaging (MPI) is still an open question. The purpose of this paper is to give a partial answer to this question. This is accomplished by numerical simulations on the dipolar interactions between two nearby SPIONs and experimental measurements on an ensemble of SPIONs using our lab-based magnetic particle spectroscopy (MPS) system.
AB - Superparamagnetic iron oxide nanoparticles (SPIONs), with comparable size to biomolecules (such as proteins, nucleic acids, etc) and unique magnetic properties, good biocompatibility, low toxicity, potent catalytic behavior, are promising candidates for many biomedical applications. There is one property present in most SPION systems, yet it has not been fully exploited, which is the dipole-dipole interaction (also called dipolar interaction) between the SPIONs. It is known that the magnetic dynamics of an ensemble of SPIONs are substantially influenced by the dipolar interactions. However, the exact way it affects the performance of magnetic particle-based bioassays and magnetic particle imaging (MPI) is still an open question. The purpose of this paper is to give a partial answer to this question. This is accomplished by numerical simulations on the dipolar interactions between two nearby SPIONs and experimental measurements on an ensemble of SPIONs using our lab-based magnetic particle spectroscopy (MPS) system.
KW - biosensors
KW - dipolar field
KW - dipole-dipole interaction
KW - magnetic particle imaging
KW - magnetic particle spectroscopy
KW - superparamagnetic nanoparticle
UR - http://www.scopus.com/inward/record.url?scp=85069723648&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069723648&partnerID=8YFLogxK
U2 - 10.1088/1361-6463/ab2580
DO - 10.1088/1361-6463/ab2580
M3 - Article
AN - SCOPUS:85069723648
SN - 0022-3727
VL - 52
JO - Journal of Physics D: Applied Physics
JF - Journal of Physics D: Applied Physics
IS - 33
M1 - 335002
ER -