The Personnel Reaction Blank (PRB) is an important personality-based instrument for assessing the integrity of individuals. Our study investigated the cross-cultural applicability of its three psychological factors (Sense of Well-being, SWB; Prosocial Background, PSB; and Compliance with Social Norms, CSN) using American and Singaporean respondent groups. Based on this three-factor structure, the PRB demonstrated acceptable cross-group generalizability. Mean scores for SWB, PSB, and CSN showed differences between male and female respondents, although the factor correlation matrices were invariant across gender. The mean composite score (SWB+PSB+CSN) was also not significantly different across gender.