Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: A pilot study

Vincent A. Magnotta; Michael L. Adix; Arvind Caprahan; Kelvin Lim; Randy Gollub; Nancy C. Andreasen

doi:10.1016/j.pscychresns.2007.10.005

Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: A pilot study

Vincent A. Magnotta, Michael L. Adix, Arvind Caprahan, Kelvin Lim, Randy Gollub, Nancy C. Andreasen

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Connections of the cortical-thalamic-cerebellar-cortical regions provide a framework for studying the neural substrates of schizophrenia. A novel diffusion tensor tractography method was used to evaluate the differences in white matter connectivity between 12 patients with schizophrenia and 10 controls. For the tract tracing, we focused on the connection between the cerebellum and the thalamus. Fractional anisotropy (FA) measures along the fiber tracks were compared between patients and the control sample. Fiber tracts located between the cerebellar white matter and the thalamus exhibit a reduced FA in patients with schizophrenia in comparison with controls. The FA values along the defined fiber tracts were not overall reduced but exhibited a reduction in the anisotropy in the region in the superior cerebellar peduncles projecting towards the red nucleus.

Original language	English (US)
Pages (from-to)	193-200
Number of pages	8
Journal	Psychiatry Research - Neuroimaging
Volume	163
Issue number	3
DOIs	https://doi.org/10.1016/j.pscychresns.2007.10.005
State	Published - Aug 30 2008

Bibliographical note

Funding Information:
This work was supported in part by the MIND Institute, a NARSAD Young Investigator award and the Nellie Ball Foundation. The authors thank Ronald Pierson, Helen Keefe and Michael Kinguta for processing the structural images.

Keywords

Diffusion tensor
Schizophrenia
Tractography

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10.1016/j.pscychresns.2007.10.005

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title = "Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: A pilot study",

abstract = "Connections of the cortical-thalamic-cerebellar-cortical regions provide a framework for studying the neural substrates of schizophrenia. A novel diffusion tensor tractography method was used to evaluate the differences in white matter connectivity between 12 patients with schizophrenia and 10 controls. For the tract tracing, we focused on the connection between the cerebellum and the thalamus. Fractional anisotropy (FA) measures along the fiber tracks were compared between patients and the control sample. Fiber tracts located between the cerebellar white matter and the thalamus exhibit a reduced FA in patients with schizophrenia in comparison with controls. The FA values along the defined fiber tracts were not overall reduced but exhibited a reduction in the anisotropy in the region in the superior cerebellar peduncles projecting towards the red nucleus.",

keywords = "Diffusion tensor, Schizophrenia, Tractography",

author = "Magnotta, \{Vincent A.\} and Adix, \{Michael L.\} and Arvind Caprahan and Kelvin Lim and Randy Gollub and Andreasen, \{Nancy C.\}",

note = "Funding Information: This work was supported in part by the MIND Institute, a NARSAD Young Investigator award and the Nellie Ball Foundation. The authors thank Ronald Pierson, Helen Keefe and Michael Kinguta for processing the structural images.",

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AU - Magnotta, Vincent A.

AU - Adix, Michael L.

AU - Caprahan, Arvind

AU - Lim, Kelvin

AU - Gollub, Randy

AU - Andreasen, Nancy C.

N1 - Funding Information: This work was supported in part by the MIND Institute, a NARSAD Young Investigator award and the Nellie Ball Foundation. The authors thank Ronald Pierson, Helen Keefe and Michael Kinguta for processing the structural images.

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N2 - Connections of the cortical-thalamic-cerebellar-cortical regions provide a framework for studying the neural substrates of schizophrenia. A novel diffusion tensor tractography method was used to evaluate the differences in white matter connectivity between 12 patients with schizophrenia and 10 controls. For the tract tracing, we focused on the connection between the cerebellum and the thalamus. Fractional anisotropy (FA) measures along the fiber tracks were compared between patients and the control sample. Fiber tracts located between the cerebellar white matter and the thalamus exhibit a reduced FA in patients with schizophrenia in comparison with controls. The FA values along the defined fiber tracts were not overall reduced but exhibited a reduction in the anisotropy in the region in the superior cerebellar peduncles projecting towards the red nucleus.

AB - Connections of the cortical-thalamic-cerebellar-cortical regions provide a framework for studying the neural substrates of schizophrenia. A novel diffusion tensor tractography method was used to evaluate the differences in white matter connectivity between 12 patients with schizophrenia and 10 controls. For the tract tracing, we focused on the connection between the cerebellum and the thalamus. Fractional anisotropy (FA) measures along the fiber tracks were compared between patients and the control sample. Fiber tracts located between the cerebellar white matter and the thalamus exhibit a reduced FA in patients with schizophrenia in comparison with controls. The FA values along the defined fiber tracts were not overall reduced but exhibited a reduction in the anisotropy in the region in the superior cerebellar peduncles projecting towards the red nucleus.

KW - Diffusion tensor

KW - Schizophrenia

KW - Tractography

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Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: A pilot study

Abstract

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