Invasive Chrysosporium Infection of the Nose and Paranasal Sinuses in an Immunocompromised Host

Frederic E. Levy, Jeanne T. Larson, Evan George, Robert H. Maisel

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Aggressive fungal rhinosinusitis with Chrysosporium sp. occurred in a patient with acute lymphocytic leukemia. The infecting organism is an exceedingly rare human pathogen. Usually, human chrysosporial infections are mild and unmarked by symptoms. Most case reports appear in the pathology literature and describe the incidental finding of adiaspores in the pulmonary parenchyma at autopsy. Clinical disease from active growth of chrysosporial mycelia in human tissues has been noted on a porcine aortic valve prosthesis and in a tibia1 abscess. Hyphal elements were not recovered from any other body parts of these patients. Histopathologic and microbiologic studies permitted the identification of this rarely encountered organism. Our patient experienced systemic spread of Chrysosporium organisms. Treatment of this pathogen is the same as for other opportunistic fungal infections.

Original languageEnglish (US)
Pages (from-to)384-388
Number of pages5
JournalOtolaryngology-Head and Neck Surgery
Volume104
Issue number3
DOIs
StatePublished - Mar 1991

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