Abstract
A 27-bp variable number tandem repeat (VNTR) in intron 4 of endothelial nitric oxide synthase (eNOS) gene has been associated with the risk for developing diabetic retinopathy (DR) in various ethnic populations. Hundred and eighty seven patients with retinopathy (cases; DR+) and 188 patients without retinopathy (controls: DR-) from southern India who had type 2 diabetes mellitus (T2DM) for more than 10 years, were included in the study. We could neither find significant allelic association with clinical severity of DR nor with macular edema. Our results suggest lack of association of intron 4 VNTR of eNOS gene with DR in southern India.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 77-81 |
| Number of pages | 5 |
| Journal | Ophthalmic Genetics |
| Volume | 28 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2007 |
Bibliographical note
Funding Information:We thank RD TATA Trust, Mumbai, India, for the financial grant and patients who participated in the study. We are very thankful to the Sankara Nethralaya Diabetic retinopathy project team for collecting the patients.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Diabetic retinopathy
- Hypoxia
- Intronic VNTR
- Type 2 diabetes
- eNOS
Fingerprint
Dive into the research topics of 'Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS