TY - JOUR
T1 - Introduction
T2 - emerging themes in DNA topoisomerase research.
AU - Clarke, Duncan J.
AU - Lane, Andrew
PY - 2009
Y1 - 2009
N2 - DNA topoisomerases are enzymes that alter the topology of DNA. They have important functions in DNA replication, transcription, Holliday junction dissolution, chromosome condensation, and sister chromatid separation. Deficiencies in these enzymes are associated with diseases that result from genome instability. The last 10-15 years has seen a great deal of exciting research in the field of topoisomerase. Here we discuss a selection of the new themes that have been recently introduced into the already large body of topoisomerase research.
AB - DNA topoisomerases are enzymes that alter the topology of DNA. They have important functions in DNA replication, transcription, Holliday junction dissolution, chromosome condensation, and sister chromatid separation. Deficiencies in these enzymes are associated with diseases that result from genome instability. The last 10-15 years has seen a great deal of exciting research in the field of topoisomerase. Here we discuss a selection of the new themes that have been recently introduced into the already large body of topoisomerase research.
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U2 - 10.1007/978-1-60761-340-4_1
DO - 10.1007/978-1-60761-340-4_1
M3 - Article
C2 - 19763937
AN - SCOPUS:73949112158
SN - 1064-3745
VL - 582
SP - 1
EP - 9
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
ER -