Intrinsically germanium-69-labeled iron oxide nanoparticles: Synthesis and in-vivo dual-modality PET/MR zimaging

Rubel Chakravarty, Hector F. Valdovinos, Feng Chen, Christina M. Lewis, Paul A. Ellison, Haiming Luo, M. Elizabeth Meyerand, Robert J. Nickles, Weibo Cai

Research output: Contribution to journalArticlepeer-review

145 Scopus citations

Abstract

Intrinsically germanium-69-labeled super-paramagnetic iron oxide nanoparticles are synthesized via a newly developed, fast and highly specific chelator-free approach. The biodistribution pattern and the feasibility of 69Ge-SPION@PEG for in vivo dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging and lymph-node mapping are investigated, which represents the first example of the successful utilization of a 69Ge-based agent for PET/MR imaging.

Original languageEnglish (US)
Pages (from-to)5119-5123
Number of pages5
JournalAdvanced Materials
Volume26
Issue number30
DOIs
StatePublished - Aug 13 2014
Externally publishedYes

Keywords

  • chelator-free radiolabeling
  • germanium-69
  • iron oxide nanoparticles
  • multimodality imaging
  • positron emission tomography/magnetic resonance (PET/MR) imaging

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