Intraventricular cholecystokinin-octapeptide produces hypothermia in rats

John E. Morley, Allen S. Levine, Sandra Lindblad

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Intraventricular administration of cholecystokinin-octapeptide (CCK-8) in unanesthetized, unrestained rats produced hyopothermia in rats. The maximum fall in temperature after CCK-8 was -1.08±0.09°C. The temperature fall after CCK-8 was significantly suppressed from 15 to 60 min after intraventricular administration and returned to basal levels by 120 min.

Original languageEnglish (US)
Pages (from-to)249-251
Number of pages3
JournalEuropean Journal of Pharmacology
Issue number2-3
StatePublished - Sep 11 1981


  • Cholecystokinin
  • Thermoregulation


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