Intraventricular cholecystokinin-octapeptide produces hyperglycemia in rats

John E. Morley; Allen S. Levine

doi:10.1016/0024-3205(81)90627-5

Intraventricular cholecystokinin-octapeptide produces hyperglycemia in rats

John E. Morley, Allen S. Levine

Medicine - Administration

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Abstract

The effect of intraventricular cholecystokinin-octapeptide (CCK-8) on blood glucose was evaluated. Intraventricular CCK-8 in rats produces hyperglycemia. The highest dose of CCK-8 (250 ng) increased plasma glucagon levels but at lower doses (2.5 and 25 ng) increases in glucose occurred without alteration in the glucagon levels. None of the doses of CCK-8 altered insulin levels. Using ¹⁴C-glucose tracer we showed that the hyperglycemia produced by CCK-8 was not due to alterations in glucose clearance.

Original language	English (US)
Pages (from-to)	2187-2190
Number of pages	4
Journal	Life Sciences
Volume	28
Issue number	19
DOIs	https://doi.org/10.1016/0024-3205(81)90627-5
State	Published - May 11 1981

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abstract = "The effect of intraventricular cholecystokinin-octapeptide (CCK-8) on blood glucose was evaluated. Intraventricular CCK-8 in rats produces hyperglycemia. The highest dose of CCK-8 (250 ng) increased plasma glucagon levels but at lower doses (2.5 and 25 ng) increases in glucose occurred without alteration in the glucagon levels. None of the doses of CCK-8 altered insulin levels. Using 14C-glucose tracer we showed that the hyperglycemia produced by CCK-8 was not due to alterations in glucose clearance.",

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AU - Levine, Allen S.

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N2 - The effect of intraventricular cholecystokinin-octapeptide (CCK-8) on blood glucose was evaluated. Intraventricular CCK-8 in rats produces hyperglycemia. The highest dose of CCK-8 (250 ng) increased plasma glucagon levels but at lower doses (2.5 and 25 ng) increases in glucose occurred without alteration in the glucagon levels. None of the doses of CCK-8 altered insulin levels. Using 14C-glucose tracer we showed that the hyperglycemia produced by CCK-8 was not due to alterations in glucose clearance.

AB - The effect of intraventricular cholecystokinin-octapeptide (CCK-8) on blood glucose was evaluated. Intraventricular CCK-8 in rats produces hyperglycemia. The highest dose of CCK-8 (250 ng) increased plasma glucagon levels but at lower doses (2.5 and 25 ng) increases in glucose occurred without alteration in the glucagon levels. None of the doses of CCK-8 altered insulin levels. Using 14C-glucose tracer we showed that the hyperglycemia produced by CCK-8 was not due to alterations in glucose clearance.

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JO - Life Sciences

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ER -

Intraventricular cholecystokinin-octapeptide produces hyperglycemia in rats

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