Abstract
The effect of intraventricular cholecystokinin-octapeptide (CCK-8) on blood glucose was evaluated. Intraventricular CCK-8 in rats produces hyperglycemia. The highest dose of CCK-8 (250 ng) increased plasma glucagon levels but at lower doses (2.5 and 25 ng) increases in glucose occurred without alteration in the glucagon levels. None of the doses of CCK-8 altered insulin levels. Using 14C-glucose tracer we showed that the hyperglycemia produced by CCK-8 was not due to alterations in glucose clearance.
Original language | English (US) |
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Pages (from-to) | 2187-2190 |
Number of pages | 4 |
Journal | Life Sciences |
Volume | 28 |
Issue number | 19 |
DOIs | |
State | Published - May 11 1981 |