Intravenous phenytoin in acute treatment of seizures

Ronald E. Cranford, Ilo E Leppik, Barbara Patrick, Charles B. Anderson, Barbara Kostick

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

Large doses of phenytoin were administered on 159 occasions to 139 adult patients. Most patients had had more than three seizures or were in status epilepticus. Based on response to treatment, patients could be divided into two groups. Those with excellent response (recurrent seizures, 10%; mortality, 1%) included known epileptics with exacerbation of seizures (n = 79, atypical alcohol withdrawal (61, or miscellaneous conditions (17). Those with poor results (recurrent seizures, 57%; mortality, 38%) included patients with anoxic or metabolic encephalopathy (14), stroke or other vascular disease (14), brain tumor (5), or trauma (5).

Original languageEnglish (US)
Pages (from-to)1474-1479
Number of pages6
JournalNeurology
Volume29
Issue number11
StatePublished - Nov 1979

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