Intravenous phenytoin: Clinical and pharmacokinetic aspects

R. E. Cranford, I. E. Leppik, B. Patrick, C. B. Anderson, B. Kostick

Research output: Contribution to journalArticlepeer-review

137 Scopus citations


Phenytoin was administered intravenously in large doses (mean = 16.6 mg per kilogram) for prevention and treatment of seizures on 159 occasions to 139 patients aged 17 to 94 years (mean = 52 years) and weighing 37 to 113 kg (mean = 65 kg). Hypotension was more frequent among older patients. No deaths were attributable to phenytoin. Volumes of distribution were relatively constant (mean = 0.78 ± 0.11 liters per kilogram), but half-lives varied considerably and were prolonged (mean = 51 ± 32 hours) because of the large doses administered. A dose of 18 mg per kilogram was effective in maintaining phenytoin serum levels above 10 pg per milliliter for 24 hours.

Original languageEnglish (US)
Pages (from-to)874-880
Number of pages7
Issue number9 I
StatePublished - 1978


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