Abstract
Intrathecal injection of substance P in mice elicited a dose-related biting and scratching response. Systemic but not intrathecal morphine sulfate antagonized this response. We interpret these observations to define a novel nociceptive response to intrathecal substance P.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 212-215 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 217 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 27 1981 |
Bibliographical note
Funding Information:This work was supported by USPHS Grants DA01933-02, T32 GM07397 and Grant RR05385. We wish to thank Ms. Cathy Cleary and Mr. Kevin Sullivan for technical assistance.
Keywords
- behavioral response
- intrathecal injection
- morphine
- mouse
- neurotransmitter
- nociception
- spinal cord
- substance P
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