Intrathecal injection of substance P in mice elicited a dose-related biting and scratching response. Systemic but not intrathecal morphine sulfate antagonized this response. We interpret these observations to define a novel nociceptive response to intrathecal substance P.
Bibliographical noteFunding Information:
This work was supported by USPHS Grants DA01933-02, T32 GM07397 and Grant RR05385. We wish to thank Ms. Cathy Cleary and Mr. Kevin Sullivan for technical assistance.
- behavioral response
- intrathecal injection
- spinal cord
- substance P