Intrathecal substance P elicits a caudally-directed biting and scratching behavior in mice

Janice L.K. Hylden, George L. Wilcox

Research output: Contribution to journalArticlepeer-review

356 Scopus citations

Abstract

Intrathecal injection of substance P in mice elicited a dose-related biting and scratching response. Systemic but not intrathecal morphine sulfate antagonized this response. We interpret these observations to define a novel nociceptive response to intrathecal substance P.

Original languageEnglish (US)
Pages (from-to)212-215
Number of pages4
JournalBrain Research
Volume217
Issue number1
DOIs
StatePublished - Jul 27 1981

Bibliographical note

Funding Information:
This work was supported by USPHS Grants DA01933-02, T32 GM07397 and Grant RR05385. We wish to thank Ms. Cathy Cleary and Mr. Kevin Sullivan for technical assistance.

Keywords

  • behavioral response
  • intrathecal injection
  • morphine
  • mouse
  • neurotransmitter
  • nociception
  • spinal cord
  • substance P

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