Intrathecal opioids block a spinal action of substance P in mice: Functional importance of both μ- and δ-receptors

Janice L.K. Hylden, George L Wilcox

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Inhibition of intrathecal substance P-elicited behavior by μ-, δ- and κ-opioids was compared. In both the substance P behavioral test and the tail flick antinociceptive test, intrathecal [D-Ala2,Met5]enkephalinamide and [D-Ala2, D-Leu5]enkephalin (DADL) were equipotent, morphine and ethylketazocine were less potent, but nalorphine was inactive. A long-lasting, highly selective, μ-receptor antagonist, β-funaltrexamine, blocked the inhibition of substance P behaviors by both morphine and ethylketazocine, but did not block the effect of DADL. These results suggest that spinal postsynaptic modulation of nociception is mediated by both δ-type and μ-type opioid agonists.

Original languageEnglish (US)
Pages (from-to)95-98
Number of pages4
JournalEuropean Journal of Pharmacology
Volume86
Issue number1
DOIs
StatePublished - Dec 17 1982

Keywords

  • Analgesia
  • Intrathecal
  • Mice
  • Opioids
  • Substance P
  • δ-Receptors

Fingerprint Dive into the research topics of 'Intrathecal opioids block a spinal action of substance P in mice: Functional importance of both μ- and δ-receptors'. Together they form a unique fingerprint.

  • Cite this