Intrathecal opioids block a spinal action of substance P in mice: Functional importance of both μ- and δ-receptors

Janice L.K. Hylden; George L Wilcox

doi:10.1016/0014-2999(82)90403-4

Intrathecal opioids block a spinal action of substance P in mice: Functional importance of both μ- and δ-receptors

Janice L.K. Hylden, George L Wilcox

Neuroscience

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Inhibition of intrathecal substance P-elicited behavior by μ-, δ- and κ-opioids was compared. In both the substance P behavioral test and the tail flick antinociceptive test, intrathecal [D-Ala²,Met⁵]enkephalinamide and [D-Ala², D-Leu⁵]enkephalin (DADL) were equipotent, morphine and ethylketazocine were less potent, but nalorphine was inactive. A long-lasting, highly selective, μ-receptor antagonist, β-funaltrexamine, blocked the inhibition of substance P behaviors by both morphine and ethylketazocine, but did not block the effect of DADL. These results suggest that spinal postsynaptic modulation of nociception is mediated by both δ-type and μ-type opioid agonists.

Original language	English (US)
Pages (from-to)	95-98
Number of pages	4
Journal	European Journal of Pharmacology
Volume	86
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(82)90403-4
State	Published - Dec 17 1982

Bibliographical note

Funding Information:
Supported by USPHS Grants DA01933, T32GM07397 and RR05385. We thank A.E. Takemori for the gift of ~-FNA.

Keywords

Analgesia
Intrathecal
Mice
Opioids
Substance P
δ-Receptors

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title = "Intrathecal opioids block a spinal action of substance P in mice: Functional importance of both μ- and δ-receptors",

abstract = "Inhibition of intrathecal substance P-elicited behavior by μ-, δ- and κ-opioids was compared. In both the substance P behavioral test and the tail flick antinociceptive test, intrathecal [D-Ala2,Met5]enkephalinamide and [D-Ala2, D-Leu5]enkephalin (DADL) were equipotent, morphine and ethylketazocine were less potent, but nalorphine was inactive. A long-lasting, highly selective, μ-receptor antagonist, β-funaltrexamine, blocked the inhibition of substance P behaviors by both morphine and ethylketazocine, but did not block the effect of DADL. These results suggest that spinal postsynaptic modulation of nociception is mediated by both δ-type and μ-type opioid agonists.",

keywords = "Analgesia, Intrathecal, Mice, Opioids, Substance P, δ-Receptors",

author = "Hylden, \{Janice L.K.\} and Wilcox, \{George L\}",

note = "Funding Information: Supported by USPHS Grants DA01933, T32GM07397 and RR05385. We thank A.E. Takemori for the gift of \textasciitilde{}-FNA.",

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doi = "10.1016/0014-2999(82)90403-4",

language = "English (US)",

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T1 - Intrathecal opioids block a spinal action of substance P in mice

T2 - Functional importance of both μ- and δ-receptors

AU - Hylden, Janice L.K.

AU - Wilcox, George L

N1 - Funding Information: Supported by USPHS Grants DA01933, T32GM07397 and RR05385. We thank A.E. Takemori for the gift of ~-FNA.

PY - 1982/12/17

Y1 - 1982/12/17

N2 - Inhibition of intrathecal substance P-elicited behavior by μ-, δ- and κ-opioids was compared. In both the substance P behavioral test and the tail flick antinociceptive test, intrathecal [D-Ala2,Met5]enkephalinamide and [D-Ala2, D-Leu5]enkephalin (DADL) were equipotent, morphine and ethylketazocine were less potent, but nalorphine was inactive. A long-lasting, highly selective, μ-receptor antagonist, β-funaltrexamine, blocked the inhibition of substance P behaviors by both morphine and ethylketazocine, but did not block the effect of DADL. These results suggest that spinal postsynaptic modulation of nociception is mediated by both δ-type and μ-type opioid agonists.

AB - Inhibition of intrathecal substance P-elicited behavior by μ-, δ- and κ-opioids was compared. In both the substance P behavioral test and the tail flick antinociceptive test, intrathecal [D-Ala2,Met5]enkephalinamide and [D-Ala2, D-Leu5]enkephalin (DADL) were equipotent, morphine and ethylketazocine were less potent, but nalorphine was inactive. A long-lasting, highly selective, μ-receptor antagonist, β-funaltrexamine, blocked the inhibition of substance P behaviors by both morphine and ethylketazocine, but did not block the effect of DADL. These results suggest that spinal postsynaptic modulation of nociception is mediated by both δ-type and μ-type opioid agonists.

KW - Analgesia

KW - Intrathecal

KW - Mice

KW - Opioids

KW - Substance P

KW - δ-Receptors

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U2 - 10.1016/0014-2999(82)90403-4

DO - 10.1016/0014-2999(82)90403-4

M3 - Article

C2 - 6186500

AN - SCOPUS:0020411144

SN - 0014-2999

VL - 86

SP - 95

EP - 98

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Intrathecal opioids block a spinal action of substance P in mice: Functional importance of both μ- and δ-receptors

Abstract

Bibliographical note

Keywords

UN SDGs

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