Intrathecal morphine in mice: A new technique

Janice L.K. Hylden; George L. Wilcox

doi:10.1016/0014-2999(80)90515-4

Intrathecal morphine in mice: A new technique

Janice L.K. Hylden
, George L. Wilcox

Neuroscience

Research output: Contribution to journal › Article › peer-review

1859 Scopus citations

Abstract

A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described. Intrathecal [³H]morphine base was not found in significant quantitities in either the midbrain or forebrain. Submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia. These effects were dose related and antagonized by subcutaneous naloxone.

Original language	English (US)
Pages (from-to)	313-316
Number of pages	4
Journal	European Journal of Pharmacology
Volume	67
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(80)90515-4
State	Published - 1980

Keywords

Analgesia
Intrathecal
Morphine
Mouse
Spinal cord

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10.1016/0014-2999(80)90515-4

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title = "Intrathecal morphine in mice: A new technique",

abstract = "A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described. Intrathecal [3H]morphine base was not found in significant quantitities in either the midbrain or forebrain. Submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia. These effects were dose related and antagonized by subcutaneous naloxone.",

keywords = "Analgesia, Intrathecal, Morphine, Mouse, Spinal cord",

author = "Hylden, \{Janice L.K.\} and Wilcox, \{George L.\}",

year = "1980",

doi = "10.1016/0014-2999(80)90515-4",

language = "English (US)",

volume = "67",

pages = "313--316",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Intrathecal morphine in mice

T2 - A new technique

AU - Hylden, Janice L.K.

AU - Wilcox, George L.

PY - 1980

Y1 - 1980

N2 - A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described. Intrathecal [3H]morphine base was not found in significant quantitities in either the midbrain or forebrain. Submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia. These effects were dose related and antagonized by subcutaneous naloxone.

AB - A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described. Intrathecal [3H]morphine base was not found in significant quantitities in either the midbrain or forebrain. Submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia. These effects were dose related and antagonized by subcutaneous naloxone.

KW - Analgesia

KW - Intrathecal

KW - Morphine

KW - Mouse

KW - Spinal cord

UR - https://www.scopus.com/pages/publications/0018956018

UR - https://www.scopus.com/pages/publications/0018956018#tab=citedBy

U2 - 10.1016/0014-2999(80)90515-4

DO - 10.1016/0014-2999(80)90515-4

M3 - Article

C2 - 6893963

AN - SCOPUS:0018956018

SN - 0014-2999

VL - 67

SP - 313

EP - 316

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

Intrathecal morphine in mice: A new technique

Abstract

Keywords

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