Intrathecal morphine in mice: A new technique

Janice L.K. Hylden, George L. Wilcox

Research output: Contribution to journalArticlepeer-review

1798 Scopus citations


A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described. Intrathecal [3H]morphine base was not found in significant quantitities in either the midbrain or forebrain. Submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia. These effects were dose related and antagonized by subcutaneous naloxone.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number2-3
StatePublished - 1980


  • Analgesia
  • Intrathecal
  • Morphine
  • Mouse
  • Spinal cord


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