TY - JOUR
T1 - Intrasubject reproducibility of growth hormone-releasing hormone-stimulated growth hormone in older women, older men, and younger men
AU - Dysken, Maurice W
AU - Skare, Stacy S.
AU - Burke, Mark S
AU - Mach, John R.
AU - Galka, Terence
AU - Billington, Charles J.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1993
Y1 - 1993
N2 - Intrasubject reproducibility of growth hormone (GH) response to growth hormone-releasing hormone (GHRH) was studied in healthy older women (n = 9), older men (n = 8), and younger men (n = 10). Subjects received IV injections of 0.1 ml/kg saline, 1 μg/kg GHRH, and 2 μg/kg GHRH, three times each, and blood was sampled at 0, 15, 30, 45, 60, and 120 min for GH concentration. There was no significant difference in peak GH response between the 1- and 2-μg/kg GHRH dosages. GH responsiveness, group variance of peak GH, and intrasubject variability were greatest for younger men, less for older men, and least for older women at both dosages of GHRH. Because of the large intrasubject variability observed in this study, it appears necessary to test subjects more than once to obtain a valid characterization of GH responsiveness.
AB - Intrasubject reproducibility of growth hormone (GH) response to growth hormone-releasing hormone (GHRH) was studied in healthy older women (n = 9), older men (n = 8), and younger men (n = 10). Subjects received IV injections of 0.1 ml/kg saline, 1 μg/kg GHRH, and 2 μg/kg GHRH, three times each, and blood was sampled at 0, 15, 30, 45, 60, and 120 min for GH concentration. There was no significant difference in peak GH response between the 1- and 2-μg/kg GHRH dosages. GH responsiveness, group variance of peak GH, and intrasubject variability were greatest for younger men, less for older men, and least for older women at both dosages of GHRH. Because of the large intrasubject variability observed in this study, it appears necessary to test subjects more than once to obtain a valid characterization of GH responsiveness.
KW - Growth hormone (GH)
KW - age
KW - gender
KW - growth hormone-releasing hormone (GHRH)
KW - intrasubject variability
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U2 - 10.1016/0006-3223(93)90099-Y
DO - 10.1016/0006-3223(93)90099-Y
M3 - Article
C2 - 8329492
AN - SCOPUS:0027225224
SN - 0006-3223
VL - 33
SP - 610
EP - 617
JO - Biological psychiatry
JF - Biological psychiatry
IS - 8-9
ER -