Intraoral administration of botulinum toxin for trigeminal neuropathic pain

Alberto Herrero Babiloni, Flavia P. Kapos, Donald R Nixdorf

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20 Scopus citations


This article presents 2 cases of different neuropathic trigeminal pain conditions treated with intraoral botulinum toxin injections. There is a growing body of evidence to support the use of this substance when administered subcutaneously in the treatment of neuropathic pain, such as in extraoral injections for trigeminal neuralgia. However, reports of intraoral submucosal administration are still lacking. In the 2 cases presented here, neuropathic pain was refractory to treatment with an important intraoral peripheral component, so onabotulinum toxin A was introduced as an adjuvant therapy. The technique, doses, and dilution are discussed. The patients reported significant reductions in pain frequency and intensity, with minimal side effects of temporary mucosal dryness and smile droopiness. The analgesic benefits of botulinum toxin may be utilized to address intraoral neuropathic pain. Further studies are needed to confirm safety and effectiveness in larger samples.

Original languageEnglish (US)
Pages (from-to)e148-e153
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Issue number6
StatePublished - Jun 1 2016


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