Intraoperative consultation for axillary sentinel lymph node biopsy: An 8-year audit

Sharon Nofech-Mozes, Wedad M. Hanna, Tulin Cil, May Lynn Quan, Claire Holloway, Mahmoud A. Khalifa

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


To summarize the authors 8-year institutional experience with intraoperative consultation via frozen section (FS) on sentinel lymph node biopsy (SLNB) in breast cancer patients we recorded the, complete operative procedure including additional surgery on the ipsilateral axilla and intraoperative consultation and permanent histopathologic processing for all cases with inoperative consultation on SLNB in breast cancer patients between the groups, χ2 and Fishers exact tests were used. Intraoperative consultation was positive in 116/706 cases (16.4%) and final pathology in 158/706 cases (22.4%); the false-negative rate was 26.6%, the false-positive rate was 0%, and the overall accuracy was 94%. False-negative rate was significantly associated with the size of metastasis (micro vs macrometastasis; P <.002) but not significantly associated with the histologic type (P = 0.76) or pathologist expertise (P = 0.08). The rate of spared second procedures was 92% when calculated exclusively for patients who ultimately underwent ALND. Intraoperative consultation via FS for SLNB is a safe practice that can reliably save clinically node-negative patients a second surgery.

Original languageEnglish (US)
Pages (from-to)129-137
Number of pages9
JournalInternational Journal of Surgical Pathology
Issue number2
StatePublished - Apr 2010
Externally publishedYes


  • Axillary lymph node dissection
  • Breast cancer
  • Intraoperative consultation
  • Micrometastasis
  • Nonsentinel lymph node
  • Sentinel lymph node biopsy
  • Subspecialty pathologist


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