PURPOSE: To report molluscum contagiosum as a cause of severe posttraumatic intraocular inflammation. METHODS: A 9-year-old girl developed severe intraocular inflammation in the right eye after a corneoscleral laceration. She underwent vitrectomy, and bacterial and fungal cultures of intraocular fluids were negative. A pedunculated white-tan mass removed from her right optic nerve head was sent for histologic evaluation. RESULT: Histologic examination of the tissue showed stratified keratinizing squamous epithelium with intracytoplasmic inclusions consistent with molluscum contagiosum. CONCLUSIONS: It is likely that infected epithelial cells were implanted at the time of injury. Vitrectomy as debridement was curative.