Intramuscular and intravenous levetiracetam in humans: Safety and pharmacokinetics

Ilo E. Leppik; Varun Goel; John Rarick; Donald R. Nixdorf; James C. Cloyd

doi:10.1016/j.eplepsyres.2010.07.016

Intramuscular and intravenous levetiracetam in humans: Safety and pharmacokinetics

Ilo E. Leppik, Varun Goel, John Rarick, Donald R. Nixdorf, James C. Cloyd

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A study in dogs demonstrated that the commercially available formulation of IV levetiracetam (LEV) could be given safely IM and was quickly and completely absorbed. In this crossover study, 5 women and 5 men were given IM and IV LEV. This study demonstrates that administration of 5. ml (500. mg) IM LEV is well tolerated and its bioavailability is equivalent to an IV injection.

Original language	English (US)
Pages (from-to)	289-292
Number of pages	4
Journal	Epilepsy Research
Volume	91
Issue number	2-3
DOIs	https://doi.org/10.1016/j.eplepsyres.2010.07.016
State	Published - Oct 2010

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Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

Half-life
Intramuscular
Intravenous
Levetiracetam
Pharmacokinetics

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10.1016/j.eplepsyres.2010.07.016

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title = "Intramuscular and intravenous levetiracetam in humans: Safety and pharmacokinetics",

abstract = "A study in dogs demonstrated that the commercially available formulation of IV levetiracetam (LEV) could be given safely IM and was quickly and completely absorbed. In this crossover study, 5 women and 5 men were given IM and IV LEV. This study demonstrates that administration of 5. ml (500. mg) IM LEV is well tolerated and its bioavailability is equivalent to an IV injection.",

keywords = "Half-life, Intramuscular, Intravenous, Levetiracetam, Pharmacokinetics",

author = "Leppik, {Ilo E.} and Varun Goel and John Rarick and Nixdorf, {Donald R.} and Cloyd, {James C.}",

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AU - Leppik, Ilo E.

AU - Goel, Varun

AU - Rarick, John

AU - Nixdorf, Donald R.

AU - Cloyd, James C.

PY - 2010/10

Y1 - 2010/10

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AB - A study in dogs demonstrated that the commercially available formulation of IV levetiracetam (LEV) could be given safely IM and was quickly and completely absorbed. In this crossover study, 5 women and 5 men were given IM and IV LEV. This study demonstrates that administration of 5. ml (500. mg) IM LEV is well tolerated and its bioavailability is equivalent to an IV injection.

KW - Half-life

KW - Intramuscular

KW - Intravenous

KW - Levetiracetam

KW - Pharmacokinetics

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JO - Epilepsy Research

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IS - 2-3

ER -

Intramuscular and intravenous levetiracetam in humans: Safety and pharmacokinetics

Abstract

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Keywords

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