Intramural dyssynchrony from acute right ventricular apical pacing in human subjects with normal left ventricular function

Alan J. Bank, David S. Schwartzman, Kevin V. Burns, Christopher L. Kaufman, Stuart W. Adler, Aaron S. Kelly, Lauren Johnson, Daniel R. Kaiser

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Ventricular pacing causes early myocardial shortening at the pacing site and pre-stretch at the opposing ventricular wall. This contraction pattern is energetically inefficient and may lead to decreased cardiac function. This study was designed to describe the acute effects of right ventricular apical (RV a) pacing on dyssynchrony and systolic function in human subjects with normal left ventricular (LV) function and compare these effects to pacing from alternate ventricular sites. Patients (n∈=∈26) undergoing an electrophysiology evaluation were studied during atrial pacing (AAI) and dual chamber pacing from the RVa, left ventricular free wall (LV fw), and the combination of RVa and LVfw (BiV). Tissue Doppler imaging was used to measure intramural dyssynchrony by utilizing an integrated cross-correlation synchrony index (CCSI) from the apical 4-chamber view. RVa and BiV pacing significantly reduced systolic function as measured by longitudinal systolic contraction amplitude (SCA long) (p∈<∈0.05) and LV velocity time integral (VTI) (p∈<∈0.05) compared to AAI and LVfw pacing. RV a (and to a lesser extent BiV) pacing resulted in septal and lateral intramural dyssynchrony as indicated by significantly (p∈<∈0.05) lower CCSI values as compared to AAI. CCSI was significantly (p∈<∈0.05) worse during RVa than LVfw pacing. In patients with normal LV function, acute ventricular pacing in the RV a alone, or in conjunction with LVfw pacing (BiV), results in impaired regional and global LV systolic function and intramural dyssynchrony as compared to LVfw pacing alone.

Original languageEnglish (US)
Pages (from-to)321-329
Number of pages9
JournalJournal of cardiovascular translational research
Volume3
Issue number4
DOIs
StatePublished - Aug 2010
Externally publishedYes

Bibliographical note

Funding Information:
study was funded by Medtronic, Inc.,

Funding Information:
Disclosures Dr. Bank receives honoraria and research grant support from Medtronic and Boston Scientific. Dr. Schwartzman is a consultant and receives research grant support from Medtronic and receives grant support from St. Jude Medical. Mr. Burns and Dr. Johnson have no disclosures. Dr. Kaufman received honoraria and research grant support from Medtronic and Boston Scientific. Dr. Adler receives honoraria and research grant support from Medtronic, Boston Scientific and St. Jude Medical. Dr. Kelly received research grant support from Medtronic and Boston Scientific. Dr. Kaiser was formerly an employee of Medtronic.

Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.

Keywords

  • Echocardiography
  • Hemodynamics
  • Mechanics
  • Pacing
  • Tissue Doppler Imaging

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