Intramolecular glycan-protein interactions in glycoproteins

Adam W. Barb, Andrew J. Borgert, Mian Liu, George Barany, David Live

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Scopus citations

Abstract

Glycoproteins are a major class of glycoconjugates displaying a variety of mutual interactions between glycan and protein moieties that ultimately affect molecular organization. Modulation of the pendant glycan structures is important in tuning the functions of glycoproteins. Here we discuss structural aspects and some of the challenges to studying intramolecular interactions between carbohydrate and protein elements in several forms of O-linked as well as N-linked glycoproteins. These illustrate the importance of the relationship of context to function in protein glycosylation.

Original languageEnglish (US)
Title of host publicationMethods in Enzymology
PublisherAcademic Press Inc.
Pages365-388
Number of pages24
EditionC
DOIs
StatePublished - 2010

Publication series

NameMethods in Enzymology
NumberC
Volume478
ISSN (Print)0076-6879

Bibliographical note

Funding Information:
This work was supported by grants from the National Institutes of General Medical Science GM066148 (D.L.) and the National Institutes of Arthritis and Musculoskeletal Diseases AR056055 (D.L.), and a fellowship from the National Institutes of Arthritis and Musculoskeletal Diseases F32AR058084 (A.B.).

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