Intramolecular glycan-protein interactions in glycoproteins

Adam W. Barb; Andrew J. Borgert; Mian Liu; George Barany; David Live

doi:10.1016/S0076-6879(10)78018-6

Intramolecular glycan-protein interactions in glycoproteins

Adam W. Barb, Andrew J. Borgert, Mian Liu, George Barany, David Live

Chemistry (Twin Cities)

Research output: Chapter in Book/Report/Conference proceeding › Chapter

29 Scopus citations

Abstract

Glycoproteins are a major class of glycoconjugates displaying a variety of mutual interactions between glycan and protein moieties that ultimately affect molecular organization. Modulation of the pendant glycan structures is important in tuning the functions of glycoproteins. Here we discuss structural aspects and some of the challenges to studying intramolecular interactions between carbohydrate and protein elements in several forms of O-linked as well as N-linked glycoproteins. These illustrate the importance of the relationship of context to function in protein glycosylation.

Original language	English (US)
Title of host publication	Methods in Enzymology
Publisher	Academic Press Inc.
Pages	365-388
Number of pages	24
Edition	C
DOIs	https://doi.org/10.1016/S0076-6879(10)78018-6
State	Published - 2010

Publication series

Name	Methods in Enzymology
Number	C
Volume	478
ISSN (Print)	0076-6879

Bibliographical note

Funding Information:
This work was supported by grants from the National Institutes of General Medical Science GM066148 (D.L.) and the National Institutes of Arthritis and Musculoskeletal Diseases AR056055 (D.L.), and a fellowship from the National Institutes of Arthritis and Musculoskeletal Diseases F32AR058084 (A.B.).

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abstract = "Glycoproteins are a major class of glycoconjugates displaying a variety of mutual interactions between glycan and protein moieties that ultimately affect molecular organization. Modulation of the pendant glycan structures is important in tuning the functions of glycoproteins. Here we discuss structural aspects and some of the challenges to studying intramolecular interactions between carbohydrate and protein elements in several forms of O-linked as well as N-linked glycoproteins. These illustrate the importance of the relationship of context to function in protein glycosylation.",

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note = "Funding Information: This work was supported by grants from the National Institutes of General Medical Science GM066148 (D.L.) and the National Institutes of Arthritis and Musculoskeletal Diseases AR056055 (D.L.), and a fellowship from the National Institutes of Arthritis and Musculoskeletal Diseases F32AR058084 (A.B.).",

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AU - Barb, Adam W.

AU - Borgert, Andrew J.

AU - Liu, Mian

AU - Barany, George

AU - Live, David

N1 - Funding Information: This work was supported by grants from the National Institutes of General Medical Science GM066148 (D.L.) and the National Institutes of Arthritis and Musculoskeletal Diseases AR056055 (D.L.), and a fellowship from the National Institutes of Arthritis and Musculoskeletal Diseases F32AR058084 (A.B.).

PY - 2010

Y1 - 2010

N2 - Glycoproteins are a major class of glycoconjugates displaying a variety of mutual interactions between glycan and protein moieties that ultimately affect molecular organization. Modulation of the pendant glycan structures is important in tuning the functions of glycoproteins. Here we discuss structural aspects and some of the challenges to studying intramolecular interactions between carbohydrate and protein elements in several forms of O-linked as well as N-linked glycoproteins. These illustrate the importance of the relationship of context to function in protein glycosylation.

AB - Glycoproteins are a major class of glycoconjugates displaying a variety of mutual interactions between glycan and protein moieties that ultimately affect molecular organization. Modulation of the pendant glycan structures is important in tuning the functions of glycoproteins. Here we discuss structural aspects and some of the challenges to studying intramolecular interactions between carbohydrate and protein elements in several forms of O-linked as well as N-linked glycoproteins. These illustrate the importance of the relationship of context to function in protein glycosylation.

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M3 - Chapter

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T3 - Methods in Enzymology

SP - 365

EP - 388

BT - Methods in Enzymology

PB - Academic Press Inc.

ER -

Intramolecular glycan-protein interactions in glycoproteins

Abstract

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