Intralesional infiltration of corticosteroids in localized langerhans’ cell histiocytosis

R. Maarten Egeler, Roby C. Thompson, P. A. Voûte, Mark E. Nesbit

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

The approaches to treatment of Langerhans’ cell histiocytosis (LCH) have been as varied as the clinical presentation of the disease. The clinical course of localized LCH of bone is generally benign, and it tends to heal spontaneously in a period of months to years. If treatment is required, the disease can be controlled by local measures such as surgical curettement, low-dose irradiation, or intralesional infiltration with corticosteroids. We reviewed 15 children treated with intralesional infiltration of corticosteroids, either primarily for disease of bone (8 patients) or as adjunctive therapy for disseminated LCH (7 patients). Two patients developed complications as a result of this treatment method.

Original languageEnglish (US)
Pages (from-to)811-814
Number of pages4
JournalJournal of Pediatric Orthopaedics
Volume12
Issue number6
DOIs
StatePublished - Jan 1 1992

Keywords

  • Complications of therapy
  • Eosinophilic granuloma of bone
  • Intralesional infiltration of corticosteroids
  • Langerhans’ cell histiocytosis

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