Intrahypothalamic discriminative stimulus effects of neuropeptide Y

E. O'Hare; James P Cleary; D. T. Weldon; J. D. Pomonis; Charles J Billington; Allen S Levine

doi:10.1016/S0091-3057(97)00456-5

Intrahypothalamic discriminative stimulus effects of neuropeptide Y

E. O'Hare
, James P Cleary
, D. T. Weldon
, J. D. Pomonis
, Charles J Billington
, Allen S Levine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Neuropeptide Y (NPY) is one of the most ubiquitous neurotransmitters in the CNS and has been implicated in a variety of psychological and physiological functions. The current study investigated whether intrahypothalamic (IH) administrations of NPY were behaviorally discriminable from saline injections. Rats were trained to differentially respond based on whether they received IH injections of NPY (0.5 μg/0.5 μl) or saline (0.5 μl 0.9% NaCl). Subjects demonstrated discriminative control (85% correct in 8 out of 10 consecutive sessions) after a mean of 32 sessions. The ability of subjects to discriminate IH NPY from saline was dose dependent, with the lowest NPY dose tested (0.03 μg/0.5 μl) generalizing to saline. The opioid antagonist naloxone blocked the discrimination of NPY when administered IP (3.0 mg/kg) or IH (50 μl).

Original language	English (US)
Pages (from-to)	375-378
Number of pages	4
Journal	Pharmacology Biochemistry and Behavior
Volume	59
Issue number	2
DOIs	https://doi.org/10.1016/S0091-3057(97)00456-5
State	Published - Feb 1998

Bibliographical note

Funding Information:
This work was supported by the Department of Veterans Affairs, by National Institute of Drug Abuse Grant DA-03999, and by the National Institutes of Diabetes and Digestive and Kidney Diseases Grant DK-42698. The authors would like to thank Joe Ghilardi for his expert technical assistance.

Keywords

Discrimination
Hypothalamus
NPY
Neuropeptide Y

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10.1016/S0091-3057(97)00456-5

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title = "Intrahypothalamic discriminative stimulus effects of neuropeptide Y",

abstract = "Neuropeptide Y (NPY) is one of the most ubiquitous neurotransmitters in the CNS and has been implicated in a variety of psychological and physiological functions. The current study investigated whether intrahypothalamic (IH) administrations of NPY were behaviorally discriminable from saline injections. Rats were trained to differentially respond based on whether they received IH injections of NPY (0.5 μg/0.5 μl) or saline (0.5 μl 0.9\% NaCl). Subjects demonstrated discriminative control (85\% correct in 8 out of 10 consecutive sessions) after a mean of 32 sessions. The ability of subjects to discriminate IH NPY from saline was dose dependent, with the lowest NPY dose tested (0.03 μg/0.5 μl) generalizing to saline. The opioid antagonist naloxone blocked the discrimination of NPY when administered IP (3.0 mg/kg) or IH (50 μl).",

keywords = "Discrimination, Hypothalamus, NPY, Neuropeptide Y",

author = "E. O'Hare and Cleary, \{James P\} and Weldon, \{D. T.\} and Pomonis, \{J. D.\} and Billington, \{Charles J\} and Levine, \{Allen S\}",

note = "Funding Information: This work was supported by the Department of Veterans Affairs, by National Institute of Drug Abuse Grant DA-03999, and by the National Institutes of Diabetes and Digestive and Kidney Diseases Grant DK-42698. The authors would like to thank Joe Ghilardi for his expert technical assistance.",

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doi = "10.1016/S0091-3057(97)00456-5",

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AU - Cleary, James P

AU - Weldon, D. T.

AU - Pomonis, J. D.

AU - Billington, Charles J

AU - Levine, Allen S

N1 - Funding Information: This work was supported by the Department of Veterans Affairs, by National Institute of Drug Abuse Grant DA-03999, and by the National Institutes of Diabetes and Digestive and Kidney Diseases Grant DK-42698. The authors would like to thank Joe Ghilardi for his expert technical assistance.

PY - 1998/2

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N2 - Neuropeptide Y (NPY) is one of the most ubiquitous neurotransmitters in the CNS and has been implicated in a variety of psychological and physiological functions. The current study investigated whether intrahypothalamic (IH) administrations of NPY were behaviorally discriminable from saline injections. Rats were trained to differentially respond based on whether they received IH injections of NPY (0.5 μg/0.5 μl) or saline (0.5 μl 0.9% NaCl). Subjects demonstrated discriminative control (85% correct in 8 out of 10 consecutive sessions) after a mean of 32 sessions. The ability of subjects to discriminate IH NPY from saline was dose dependent, with the lowest NPY dose tested (0.03 μg/0.5 μl) generalizing to saline. The opioid antagonist naloxone blocked the discrimination of NPY when administered IP (3.0 mg/kg) or IH (50 μl).

AB - Neuropeptide Y (NPY) is one of the most ubiquitous neurotransmitters in the CNS and has been implicated in a variety of psychological and physiological functions. The current study investigated whether intrahypothalamic (IH) administrations of NPY were behaviorally discriminable from saline injections. Rats were trained to differentially respond based on whether they received IH injections of NPY (0.5 μg/0.5 μl) or saline (0.5 μl 0.9% NaCl). Subjects demonstrated discriminative control (85% correct in 8 out of 10 consecutive sessions) after a mean of 32 sessions. The ability of subjects to discriminate IH NPY from saline was dose dependent, with the lowest NPY dose tested (0.03 μg/0.5 μl) generalizing to saline. The opioid antagonist naloxone blocked the discrimination of NPY when administered IP (3.0 mg/kg) or IH (50 μl).

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Intrahypothalamic discriminative stimulus effects of neuropeptide Y

Abstract

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Keywords

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