Abstract
Background: There is a growing interest in large-scale connectivity as one of the crucial factors in working memory. Correlative evidence has revealed the anatomical and electrophysiological players in the working memory network, but understanding of the effective role of their connectivity remains elusive. Objective: In this double-blind, placebo-controlled study we aimed to identify the causal role of theta phase connectivity in visual-spatial working memory. Methods: The frontoparietal network was over- or de-synchronized in the anterior-posterior direction by multi-electrode, 6Hz transcranial alternating current stimulation (tACS). Results: A decrease in memory performance and increase in reaction time was caused by frontoparietal intrahemispheric desynchronization. According to the diffusion drift model, this originated in a lower signal-to-noise ratio, known as the drift rate index, in the memory system. The EEG analysis revealed a corresponding decrease in phase connectivity between prefrontal and parietal areas after tACS-driven desynchronization. The over-synchronization did not result in any changes in either the behavioral or electrophysiological levels in healthy participants. Conclusion: Taken together, we demonstrate the feasibility of manipulating multi-site large-scale networks in humans, and the disruptive effect of frontoparietal desynchronization on theta phase connectivity and visual-spatial working memory.
Original language | English (US) |
---|---|
Pages (from-to) | 147-158 |
Number of pages | 12 |
Journal | Restorative Neurology and Neuroscience |
Volume | 35 |
Issue number | 2 |
DOIs | |
State | Published - Jan 1 2017 |
Bibliographical note
Funding Information:IA conceptualized the study. IA, AA, and WP designed the experiments. SCP collected the data. IA analyzed the data. AA and WP supervised the study. IA, SCP, AA, and WP wrote the paper. We thank Dr. Zsolt Turi for inspiring discussions regarding the present study and Christine Crozier for proofreading the manuscript. This work was supported by the Deutsche Forschungsgemeinschaft (SPP 1665 to WP).
Publisher Copyright:
© 2017 IOS Press and the authors. All rights reserved.
Keywords
- Connectivity
- EEG
- frontoparietal network
- tACS
- theta rhythm
- working memory
PubMed: MeSH publication types
- Journal Article
- Randomized Controlled Trial
- Research Support, Non-U.S. Gov't